by Duke University Medical Center The summary model. (Left) A zoomed-in peripheral perivascular site. During IgE-mediated anaphylaxis, IgE-sensitized MCs are activated systemically when allergens bind to IgE, leading to extensive degranulation. Once released, granules fall on nearby nerve fibers, and this promotes the targeted release of multiple MC mediators to nerve fibers. Our study showed that...
by University of Cambridge A transmission electron micrograph of SARS-CoV-2 virus particles (UK B.1.1.7 variant), isolated from a patient sample and cultivated in cell culture. Credit: NIAID Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists. Scientists at the Cambridge Institute of Therapeutic...
by Hong Kong Baptist University MT1-MMP+ACE2+ lung epithelial cells are susceptible to SARS-CoV-2 infection. a MT1-MMP+ cells were distributed across the indicated cell types in the human lung within UMAP. b Heat map analysis of MMP14 gene expression in various lung and airway cells. c The distribution of ACE2+ and ACE2+ MT1-MMP+ cells in the lung was assessed using human...
By Michael Irving March 19, 2023 A new technique could pave the way for off-the-shelf immunotherapies for cancer Depositphotos Scientists at ETH Zurich have made a breakthrough towards designing an off-the-shelf treatment for immunotherapy against cancer. A synthetic protein tweak can allow immune cells from any donor to be given to any patient without the risk of...
by Rice University The disk-shaped 3D scaffolds used to model the tumor microenvironment mimics bone structure and texture. Credit: Gustavo Raskosky/Rice University Tumor cells won’t show their true selves in a petri dish, isolated from other cells. To find out how they really behave, Rice University researchers developed an upgraded tumor model that houses osteosarcoma cells...
by Justin Jackson , Medical Xpress Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.02.017 Researchers at Stanford University in California have devised a fluorescence-activated cell-sorting method for isolating distinct neural stem and progenitor cell types from human brain tissue. The markers used in the study are conserved across diverse brain regions. The technique should aid future research on...
by Justin Jackson , Medical Xpress GRS performance. a, Prediction performance of three GRSs across ancestry groups for FEV1/FVC shown as the s.d. change in FEV1/FVC per s.d. increase in GRS for individuals in the UK Biobank grouped according to ancestry. Sample sizes: AFR, n = 4,227; AMR, n = 2,798; EAS, n = 1,564; and EUR, n = 320,656. b, Prediction performance...
Scientists are searching for medications that will have fewer side effects for people with heart failure. Orlando/Getty Images Heart failure is a severe condition concerning how well the heart can pump blood throughout the body. The management of heart failure involves lifestyle modifications and the use of certain medications. A recent study tested the hormone...
Batya Swift Yasgur, MA, LSW March 16, 2023 A common chemical that is used in correction fluid, paint removers, gun cleaners, aerosol cleaning products, and dry cleaning may be the key culprit behind the dramatic increase in Parkinson’s disease (PD), researchers say. An international team of researchers reviewed previous research and cited data that suggest the chemical trichloroethylene (TCE) is associated with as...
by Cynthia Weiss Credit: Pixabay/CC0 Public Domain DEAR MAYO CLINIC: My family observes Ramadan, the Muslim holy month which involves fasting. However, I recently was diagnosed with diabetes. Another relative with diabetes told me that it would not be possible for me to fast. Do you have advice for how I can safely participate in...
