by Elana Gotkine Recommendations have been updated for screening and testing for hepatitis B virus (HBV) infection, according to research published in the March 10 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report. Erin E. Conners, Ph.D., from the CDC in Atlanta, and colleagues updated and expanded the previously...
Child and teen mortality in the US experiences largest increase in decades
VIRGINIA COMMONWEALTH UNIVERSITY RICHMOND, Va. (March 13, 2023) — Child and adolescent mortality rates in the United States rose by 20% between 2019 and 2021, the largest increase in at least 50 years, according to an editorial published Monday in the Journal of the American Medical Association. These increases follow decades of progress in lowering the rate of death from...
The fat tax: Long-term, systemic antibiotic use for the treatment of adolescent acne can promote fat accumulation
MEDICAL UNIVERSITY OF SOUTH CAROLINA IMAGE: MINOCYCLINE TREATMENT (RIGHT) INCREASED ABDOMINAL ADIPOSITY, COMPARED TO CONTROLS (LEFT). YELLOW = SUBCUTANEOUS ADIPOSE; GREEN = VISCERAL ADIPOSE. CREDIT: MATTHEW CARSON AND DR. CHAD NOVINCE OF THE MEDICAL UNIVERSITY OF SOUTH CAROLINA. A growing body of evidence is showing that the healthy gut microbiome – a community of microorganisms that live...
Prostate cancer treatment can wait for most men, study finds
by Carla K. Johnson This 1974 microscope image made available by the Centers for Disease Control and Prevention shows changes in cells indicative of adenocarcinoma of the prostate. A study published by the New England Journal of Medicine on Saturday, March 11, 2023, finds long-term evidence that actively monitoring prostate cancer can be a safe...
Study: Diabetes and tooth loss together worsen cognitive decline
by New York University Trajectories of cognitive decline over time by baseline diabetes mellitus (DM) and edentulism status. Solid line, with neither condition; dashed line, with DM only; dashed and dotted line, with edentulism only; dotted line, with both conditions. Shaded areas are 95% confidence intervals (CIs). Estimated rates of cognitive decline: older adults aged...
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A new control switch could make RNA therapies easier to program
MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic genes are activated only in specific cells. The researchers demonstrated that...
Antibody fragment-nanoparticle therapeutic eradicates cancer
CORNELL UNIVERSITY ITHACA, N.Y. — A novel cancer therapeutic, combining antibody fragments with molecularly engineered nanoparticles, permanently eradicated gastric cancer in treated mice, a multi-institutional team of researchers found. The results of the “hit and run” drug delivery system, published in the March issue of Advanced Therapeutics, were the culmination of more than five years of collaboration between Cornell,...
Fomepizole helps overcome antibiotic-resistant pneumonia in mice
PLOS IMAGE: FOR ANAEROBIC BACTERIA, FERMENTATION PATHWAYS ARE VITAL TO MAINTAIN ENERGY PRODUCTION. THEIR BLOCKING, SUCH AS WITH FOMEPIZOLE, DISRUPTS ENERGY PRODUCTION AND THIS ENHANCES THE SUSCEPTIBILITY OF BACTERIA TO ANTIMICROBIALS. CREDIT: CARLOS J. ORIHUELA (CC-BY 4.0, HTTPS://CREATIVECOMMONS.ORG/LICENSES/BY/4.0/) Pneumococcal disease leads to over three million hospitalizations and hundreds of thousands of deaths annually. A study publishing...