BRIGHAM AND WOMEN’S HOSPITAL Brigham and Boston Medical Center researchers found that different types of kidney damage are associated with the chances of developing and dying from heart disease Findings highlight the individual differences in cardiovascular risk for patients with kidney disease Chronic kidney disease (CKD) is an independent risk factor for heart diseases, such as heart...
Month: <span>March 2023</span>
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Discovery of T cells’ role in Alzheimer’s, related diseases, suggests new treatment strategy
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer’s disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms. Many of the immunity-focused Alzheimer’s drugs...
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New Insights by Mass General on the molecular mechanism of hydrocephalus could lead to the first-ever non-surgical treatment
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans. As reported in the journal Cell, the team uncovered in animal models the pathway through which infection or...
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Modifying messenger RNA may provide a new target for Alzheimer’s disease
by Public Library of Science Credit: Unsplash/CC0 Public Domain Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in a mouse model, according to a new study publishing March 7 in the open access journal PLOS Biology by Rui Zhang of Air Force Medical...
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Researchers develop blood test for anxiety
by Indiana University School of Medicine Discovery, prioritization, and validation of biomarkers for anxiety. A Cohorts used in study, depicting flow of discovery, prioritization, validation of biomarkers from each step and independent testing cohorts. B Discovery cohort longitudinal within-subject analysis. Phchp### is study ID for each subject. V# denotes visit number. Red are high anxiety...
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New bone cancer drug improves survival rates by 50% in preclinical trials
by University of East Anglia Credit: Pixabay/CC0 Public Domain Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer. Cancer that starts in the bones, rather than cancer that has spread to the bones, predominantly affects children. Current treatment is grueling, with...
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Spinal cord stimulation doesn’t help with back pain, says new review
by University of Sydney X-ray of a human spinal column with spinal cord stimulator implant. Credit: Mconnell, CC BY 3.0 creativecommons.org/licenses/by/3.0, via Wikimedia Commons, commons.wikimedia.org/wiki/File:Anterior_thoracic_SCS.jpg Spinal cord stimulation, a medical technology suggested to treat people with chronic back pain, does not provide long-term relief and may cause harm, according to a Cochrane Review released today. Spinal cord...
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First nasal monoclonal antibody treatment for COVID-19 shows promise for treating virus, other diseases
by Brigham and Women’s Hospital Credit: Unsplash/CC0 Public Domain A pilot trial by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system, tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody. Investigators found evidence that the drug dampened the inflammatory T cell response and...
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Could having an irregular heart rhythm affect a person’s risk of developing dementia?
by Wiley Credit: Pixabay/CC0 Public Domain In a large study of diverse adults in California, individuals with newly diagnosed atrial fibrillation, or an irregular heart rhythm, had a modestly elevated risk of developing dementia. The Journal of the American Heart Association study found that this risk was higher in younger adults and those without chronic kidney disease,...
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Study reveals new insights into cause of certain heart rhythm disorders
by The Ohio State University Graphical abstract. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI152071 A study by researchers at The Ohio State University reveals new insights into the cause of certain cardiac arrhythmia disorders. The findings may lead to new treatments. The study focused on a protein called calmodulin, which is found in many organs of the body....