by American Society for Biochemistry and Molecular Biology Graphical abstract. Credit: Molecular & Cellular Proteomics (2023). DOI: 10.1016/j.mcpro.2023.100503 A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells. The authors published their results in Molecular & Cellular Proteomics. Acute myeloid leukemia is a cancer of developing immune cells. It can manifest...
Gene variants linked to cerebral arachnoid cysts overlap with developmental disorders, autism, and epilepsy
by Justin Jackson, Medical Xpress Graphical summary of the methodological framework of the study. Credit: Nature Medicine (2023). DOI: 10.1038/s41591-023-02238-2 The most common type of brain cyst (arachnoid) has no known cause. New research investigating patients with these cysts has found something unexpected—a potential genetic link. A team led by Yale University School of Medicine has gathered health history and exome...
Battling drug resistant bacteria with bacteriophages
by NanJing Agricultural University Examples of the combination of nanotechnology with phages. (A) Use of phages conjugated with gold NPs for the identification of bacteria (detection, sensing, typing) based on color changes due to their surface plasmon resonance properties. (B) Use of phages conjugated with gold nanorods (AuNRs) for focalized photothermal therapy. (C) Encapsulation and adsorption...
Chinese team creates vocal cords on a chip
by Peter Grad, Tech Xplore Speech interaction paradigm based on the wearable AT. Credit: Nature Machine Intelligence (2023). DOI: 10.1038/s42256-023-00616-6 Most of us take our voices for granted. But if we sing too long at a wild party, scream for our team at a sports event or suffer a bout of laryngitis due to a cold, we...
Getting under your skin for better health
The next frontier of continuous health monitoring could be skin deep. Testing of interstitial fluid could one day replace bloodwork for health and wellness. Biomedical engineers at the University of Cincinnati say interstitial fluid, the watery fluid between and around cells, tissues and organs in the body, could provide an excellent medium for early disease diagnosis or long-term health...
Brain tumor discovery paves way for new drug treatments
UNIVERSITY OF NOTTINGHAM New research has shown that the blood vessels that feed aggressive brain tumours have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumours of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves. Scientists from...
Novel biomimetic polypeptides activate tumor-infiltrating macrophages, offering hope for cancer therapy
NANJING AGRICULTURAL UNIVERSITY THE ACADEMY OF SCIENCE IMAGE: THE TFOLD-PREDICTED PROTEIN STRUCTURE OF A BMPP COMPRISING (GGSGGPGGGPASAAANSASRATSNSP)N, THE RGD MOTIF FROM COLLAGEN AND THE IKVAV MOTIF FROM LAMININ, DESIGNED BY A RESEARCH TEAM FROM CHINA. BMPPS CAN ACTIVATE THE M1 PHENOTYPE OF MACROPHAGES, WHICH CAN BE USED FOR IMMUNOTHERAPY AGAINST CANCER. CREDIT: NA KONG FROM...
AI accurately identifies normal and abnormal chest x-rays
RADIOLOGICAL SOCIETY OF NORTH AMERICA IMAGE: IMAGES IN A 44-YEAR-OLD MAN WHO PRESENTED WITH CHEST PAIN AND DYSPNEA. (A) CHEST X-RAY SHOWS VERY SUBTLE NODULAR OPACITIES, PRIMARILY IN LOWER LOBES, REPRESENTATIVE OF PNEUMONIA AND A DISCRETE SILHOUETTE SIGN OF THE RIGHT CARDIAC BORDER (ARROW). THE AI SYSTEM INTERPRETED THIS CHEST X-RAY AS NORMAL. IT WAS...
Magnetically actuated quadruped soft microrobot toward gastric biopsy
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: SCHEMATIC DIAGRAM OF THE BIONIC WALKING AND GRIPPING OF THE MAGNETICALLY ACTUATED QUADRUPED SOFT MICROROBOT TOWARD GASTRIC BIOPSY. CREDIT: CHENYANG HUANG, SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES Recently, a research team from Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, proposed a bionic quadruped soft...
Cited1 links sex and metabolic hormones to protect against obesity
HELMHOLTZ MUNICH (HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR IMAGE: CITED1 (BLUE), POMC (GREEN) AND LEPTIN RECEPTOR (RED) IMMUNOREACTIVITY IN THE ARCUATE HYPOTHALAMUS. CREDIT: ©CRISTINA GARCIA-CACERES Sex differences exist in the regulation of energy homeostasis, the organism’s mechanism to keep a stable body weight. Current studies indicate for instance that female mammals, including humans, are better...