By Simon Makin on March 1, 2023 Credit: Thomas Fuchs Artificial enzymes can fight the COVID-causing virus by selectively snipping apart its RNA genome, a new study suggests. Researchers say the technique may overcome key problems with previous technologies and could help create rapid antiviral treatments as threats emerge. When the COVID pandemic struck, University of Cambridge chemical...
Light-induced acceleration of intracellular delivery
by Osaka Metropolitan University Light-induced accelerating system to increase the concentration of biofunctional molecules around targeted cells and their cytosolic delivery. Credit: Ikuhiko Nakase, and Takuya Iida, OMU Cell membranes are barriers that maintain cellular homeostasis, and the intracellular delivery of biologically functional molecules, including peptides, proteins, and nucleic acids to manipulate cellular functions. Conventional...
COVID pill is first to cut short positive-test time after infection
Mariana Lenharo Particles of SARS-CoV-2 (blue; artificially coloured) infect a cell.Credit: Steve Gschmeissner/SPL COVID-19 can inflict days of misery, even on people who do not develop serious illness. Now, trial data show that an antiviral called ensitrelvir shortens symptoms of mild to moderate COVID-19 by about a day — and is the first drug to make a...
Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus
SCIENCE CHINA PRESS IMAGE: THE TAXONOMIC PROFILE AND THE INTERFERON-Α-STIMULATORY CAPACITY OF GUT VIRUS-LIKE PARTICLES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS CREDIT: ©SCIENCE CHINA PRESS This study is led by Prof. Xuan Zhang (Beijing Hospital) and Prof. Jun Wang (Chinese Academy of Sciences). Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that can affect...
Researchers investigate the influence of oxidative stress on peptide aggregation
UNIVERSITÄT LEIPZIG IMAGE: OXIDISED MODEL MEMBRANES HAVE DIFFERENT EFFECTS ON PEPTIDE FIBRIL FORMATION, DRIVEN BY MEMBRANE SURFACE ATTRACTION, PEPTIDE CHARGE AND PEPTIDE STRUCTURAL PROPERTIES. CREDIT: LEIPZIG UNIVERSITY The researchers wanted to better understand how cell membranes in the body influence the structure of peptides – these are molecules made up of amino acids – and their aggregation....
A Pitt lab shows phage attacks in new light
UNIVERSITY OF PITTSBURGH VIDEO: INFECTION OF MYCOBACTERIUM SMEGMATIS BY A GENETICALLY ENGINEERED MUTANT OF PHAGE FIONNBHARTH. THREE STEPS IN THE INFECTION PROCESS CAN BE SEEN: 1) A SINGLE PHAGE PARTICLE BINDS TO THE BACTERIAL CELL, AND IS SEEN AS A RED DOT 0.42 SECONDS INTO THE VIDEO. 2) TWO SECONDS INTO THE MOVIE, GREEN FLUORESCENCE...
Math used to help calculate more effective prostate cancer treatments
By Paul McClure March 05, 2023 A mathematical model has been used to compare the effectiveness of single-drug and combination-drug treatment of prostate cancer Depositphotos The prevalence of prostate cancer around the world means that finding an effective treatment is critical. A new UK study has used mathematics to investigate the effectiveness of some currently...
Laser used to spot and identify bacteria in a matter of minutes
By Ben Coxworth March 03, 2023 A Stanford University logo made up of droplets containing bacteria and red blood cells, printed onto a gold-coated slideFareeha Safir Currently, in order to see what type of bacteria (if any) are present in a liquid sample, bacterial cultures have to be grown in a lab over the course...
Experimental vaccine reprograms cancer to launch immunotherapy attack
By Michael Irving March 05, 2023 Cancer cells can be converted into cells that help the immune system launch an attack on the disease, according to a new study Depositphotos Scientists have developed a new type of cancer vaccine that shows promise in clearing out leukemia in mice. The technique involves reprogramming cancer cells into...
Trouble falling asleep at bedtime or in the middle of the night? It could impact your risk for developing dementia
ELSEVIER Ann Arbor, March 6, 2023 – Adding to the growing body of evidence on sleep disturbances and cognitive impairment, new research finds significant links between three measures of sleep disturbance and the risk for developing dementia over a 10-year period. The results, reported in the American Journal of Preventive Medicine, published by Elsevier, associate sleep-initiation insomnia (trouble falling asleep within 30...