by Krista Conger, Stanford University MYC regulated St6galnac4 promotes display of the glycan disialyl-T. (A) Murine T-ALL cell surface sialic acids were quantified at various time points after doxycycline administration to turn off expression of the MYC transgene. Sialic acids were detected via oxidation with mild periodate treatment and subsequent labeling with an aminooxy-biotin probe...
March 24, 2023 02:40 PM EDT Updated 13 hours ago R&D Pharma Katherine Lewin News Reporter Novo Nordisk is testing higher levels of its oral version of its GLP-1, semaglutide, and its type 2 diabetes trial results released today show reductions in blood sugar as well as weight loss. In the Phase IIIb trial, Novo...
Abstract Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and...
by California Institute of Technology A smart bandage rests on a gloved finger. Credit: Caltech Most of the time, when someone gets a cut, scrape, burn or other wound, the body takes care of itself and heals on its own. But this is not always the case. Diabetes can interfere with the healing process and create...
Endometriosis is a disease that can cause pain and infertility, and currently, there is no cure for it. Researchers at the University of Oxford in the United Kingdom studied DNA samples from thousands of female participants to see if there is a genetic component underlying endometriosis. The researchers collaborated with 25 teams internationally to obtain and...
by Julie Kiefer, University of Utah Health Sciences Credit: Unsplash/CC0 Public Domain One in 40 Utah children aged eight years have been identified with autism spectrum disorder (ASD), according to a newly published analysis led by the U.S. Centers for Disease Control and Prevention in collaboration with scientists across the country including at Huntsman Mental Health Institute....
by Burnet Institute Credit: New England Journal of Medicine (2022). DOI: 10.1056/NEJMoa2117166 New World Health Organization (WHO) guidelines for the treatment of drug resistant tuberculosis (DR-TB) are shaping as a game changer for the estimated 500,000 people diagnosed with DR-TB each year, and the longer-term goal to end the global TB pandemic by 2035. The guidelines are based on...
By CASSIDY MORRISON SENIOR HEALTH REPORTER FOR DAILYMAIL.COM UPDATED: 15:12 EDT, 23 March 2023 A flurry of US deaths and blindness caused by contaminated eyedrops has caused panic nationwide. Three Americans have died, eight have suffered vision loss and four people have had to have their eyeballs removed after becoming infected with a rare drug-resistant strain of...
by Tel Aviv University SPECT analysis. A. Increased post treatment activation in Brodmann areas (BAs) in HBOT group compared to Medication group. B. Pearson correlation coefficient heatmap representing changes in BAs activation and questionnaire scores. The parameters are ordered by hierarchical clustering using the Euclidian distance metric algorithm. Credit: PLOS ONE (2023). DOI: 10.1371/journal.pone.0282406 Researchers from Tel...
by Elana Gotkine Statin use is low for primary prevention of atherosclerotic cardiovascular disease (ASCVD), with the lowest use seen among Black and Hispanic adults, according to a study published online March 22 in JAMA Cardiology. Joshua A. Jacobs, Pharm.D., from the Spencer Fox Eccles School of Medicine at the University of Utah in Salt Lake...
