by University of Pittsburgh Credit: Pixabay/CC0 Public Domain A group of University of Pittsburgh researchers has given new meaning to “knowing your ABCs.” In a new study, published in the Journal of Experimental Medicine, the team showed that a type of immune cell called age-associated B cells, or ABCs, are important drivers of lupus and that targeting these...
by Aalto University T cells recognise harmful invaders in the body from their molecular signatures and are able to form an immunological memory for future incursions. Credit: Matti Ahlgren/Aalto University Researchers at Aalto University, the University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center have studied how a completely new treatment option affects the immune...
by Public Library of Science Drosophila that represents one of the models of neurodegeneration used in the lab to screen for things (both chemically and genetically) that regulate mitophagy. Credit: Angus McQuibban (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/) The words that researchers use to describe their results can be harnessed to discover potential new treatments for Parkinson’s disease, according to a...
by Brandon Chase, Massachusetts General Hospital Credit: Pixabay/Pete Linforth. Although investigators have made strides in detecting signs of Alzheimer’s disease using high-quality brain imaging tests collected as part of research studies, a team at Massachusetts General Hospital (MGH) recently developed an accurate method for detection that relies on routinely collected clinical brain images. The advance could lead...
According to recent research, a set of 10 signaling proteins found in the microbe that causes tuberculosis [TB] play a far larger role in regulating the bacterium’s growth, development, and behavior than previously thought. The UW School of Medicine and Seattle Children’s researchers led the study. TB remains a deadly disease that kills more than...
GARVAN INSTITUTE OF MEDICAL RESEARCH IMAGE: 2-PHOTON MICROSCOPE IMAGE OF THE GERMINAL CENTRE INSIDE A LYMPH NODE, SHOWING B CELLS (GREEN) MOVING AROUND AND A TINGIBLE BODY MACROPHAGE (RED) GRABBING THE DEAD AND DYING B CELLS CREDIT: GARVAN For almost 140 years, the origin and behaviour of an enigmatic cell type inside lymph nodes, called...
HUBRECHT INSTITUTE IMAGE: HEART MUSCLE CELLS WITHOUT (WILDTYPE) OR WITH (MUTANT) THE NEWLY DISCOVERED MUTATION. PROTEINS THAT ARE PRESENT IN HEART MUSCLE CELLS SPECIFICALLY (GREEN), DESMOSOMAL PROTEINS (RED) AND CELL NUCLEI (BLUE) ARE VISIBLE. CREDIT: JANTINE MONSHOUWER-KLOOTS, COPYRIGHT HUBRECHT INSTITUTE Researchers from the group of Eva van Rooij in collaboration with the UMC Utrecht identified a...
MEMORIAL SLOAN KETTERING CANCER CENTER • The blood-brain barrier prevents most drugs from reaching brain tumors.• A new method using nanoparticles transported drugs across this barrier in mice.• The nanoparticles target a protein on tumor blood vessel cells called P-selectin.• The nanoparticles improved the treatment in a model of aggressive pediatric brain cancer Brain tumors...
by Virginia Commonwealth University Model for the functional interaction between Smad4 and Prdm16 during PDAC formation and progression. Credit: Journal of Cell Biology (2023). DOI: 10.1083/jcb.202203036 Scientists at VCU Massey Cancer Center have uncovered a previously unrecognized relationship between two sets of proteins that operate in tandem to fend off the growth of pancreatic cancer. The findings...
by The Francis Crick Institute Credit: Pixabay/CC0 Public Domain Scientists from Barts Cancer Institute at Queen Mary University of London and the Francis Crick Institute, have uncovered why patients with a rare type of blood cancer suffer from ineffective red blood cell production, and how vitamin B5 could be combined with existing drugs to improve...
