MARCH 1ST, 2023 CONN HASTINGS DIAGNOSTICS, MATERIALS Scientists at the University of Massachusetts Amherst have developed a biosensor that is based on protein nanowires that are created by bacteria. The protein nanowires are highly sensitive to ammonia, in this case, which is present in the breath of patients with kidney disease, but it is likely possible...
CENTER FOR GENOMIC REGULATION IMAGE: FROM LEFT TO RIGHT: NOEMÍ HARO, ÓSCAR POZO, INMA HERNÁNDEZ-MUÑOZ, EVELYN ANDRADES, PALOMA TORRES & RAMON PUJOL CREDIT: HOSPITAL DE MAR/IMIM Cells that form cutaneous squamous cell carcinoma tumours prepare themselves to migrate to the lymph nodes to metastasise other organs, and they make changes so that they can survive...
THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (March 1, 2023)—Approximately 33% of American women will experience overactive bladder syndrome (OAB), which interferes with daily activities, social functioning, and sleep quality. There have been few studies focused on treatments for this disorder. A new study suggests that vaginal laser surgery may be effective in treating...
UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER IMAGE: IN A NEW STUDY PUBLISHED IN PNAS, INVESTIGATORS AT HARRINGTON DISCOVERY INSTITUTE AND CASE WESTERN RESERVE SCHOOL OF MEDICINE SHOWED THAT A MODIFIED VERSION OF HEMOGLOBIN, TERMED S-NITROSOHEMOGLOBIN, SENSES AREAS WITH INSUFFICIENT OXYGEN, AND THEN RESTORES BLOOD FLOW FOR OXYGENATION. CREDIT: CANVA CLEVELAND—Cardiovascular medicine, hematology and pulmonary medicine may...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – In people with type 1 diabetes, the body’s immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets. In research published in Cell Reports Medicine, a team led by investigators at Massachusetts General...
by The Scripps Research Institute Detailed structural imagery of public bnAbs and where they bind to SARS-CoV-2 (green helix) and MERS-CoV (orange helix). These bnAbs recognize the S2 region of the viral spike protein, which is relatively conserved and could lead to the development of a broad coronavirus vaccine and related antibody therapies. Credit: The...
by American Chemical Society Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.2c01369 Certain diseases, including Alzheimer’s, are currently considered “undruggable” because traditional small molecule drugs can’t interfere with the proteins responsible for the illnesses. But a new technique that specifically targets and breaks apart certain proteins—rather than just interfering with them—may offer a pathway toward treatment....
by Institute of Cancer Research Acute depletion of SET1/COMPASS core subunits reveals rapid turnover of H3K4me3. a, Schematic of the degron systems for the targeted degradation of DPY30 and RBBP5. b,c, Immunoblot analysis of DPY30, RBBP5 and H3K4me1–3 levels at the indicated times after treatment with 500 nM auxin (b) or 500 nM dTAG-13 (c). Washout, degron ligand was...
by The Reis Group Credit: Unsplash/CC0 Public Domain A minimally invasive treatment that injects allograft disk tissue into the spine to relieve pain associated with degenerative disk disease provides significant improvement in pain and function over a sustained period, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Phoenix, March 4–9....
by Courtney Chandler, University of Connecticut A simple, portable, CRISPR-powered microfluidic biosensor for HIV virus detection using a personal glucose meter. Credit: Changchun Liu HIV is one of the world’s most serious public health challenges, and molecular detection plays a significant role in early diagnosis and antiretroviral therapy for HIV patients. The current “gold standard”...
