Month: <span>March 2023</span>

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Researchers unravel new mechanisms behind articular cartilage healing after injury
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Researchers unravel new mechanisms behind articular cartilage healing after injury

by University of Eastern Finland New computational model was able to predict experimentally observed degradation and unravel the mechanisms behind partial recovery of injured articular cartilage. Credit: Joonas P. Kosonen Understanding how the knee joint environment affects cartilage cells is crucial for joint health. Knowledge of cell-driven cartilage degeneration mechanisms can support the development of...

Explaining why some patients may test positive for COVID-19 long after recovery
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Explaining why some patients may test positive for COVID-19 long after recovery

by Greta Friar, Whitehead Institute for Biomedical Research Cells that have had a bit of SARS-CoV-2 mRNA put into them. DNA is in blue and the SARS-CoV-2 protein is in red. Credit: Liguo Zhang/ Whitehead Institute SARS-CoV-2, the virus that causes COVID-19, seems to have become a permanent presence in our lives. Research from Whitehead Institute Founding...

Predicting development of ALS disease with AI methods
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Predicting development of ALS disease with AI methods

by Bielefeld University The architecture of DiseaseCapsule. The input is the concatenation of the compressed features from all Gene-PCA models, where each feature corresponds to one Gene-PCA. The number of Gene-PCAs is 75,584, so the dimensionality of the input is 75,584 × 1. DiseaseCapsule consists of three layers: a fully connected layer (FC), a primary capsule layer...

Biological oxygen tank for stem cells boosts brain tissue repair
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Biological oxygen tank for stem cells boosts brain tissue repair

By Bronwyn Thompson February 28, 2023 The right biochemical environment is crucial for stem cell survival Depositphotos The race is on to regenerate damaged tissue as a result of brain injury from the likes of stroke. But one of the many barriers to the success of stem cell biotechnology has been keeping cells alive long...

Alzheimer’s study links cholesterol and toxic protein clusters
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Alzheimer’s study links cholesterol and toxic protein clusters

by Texas A&M University Dmitry Kurouski, Ph.D., standing, and research assistant Kiryl Zhaliazka, conducted a study linking cholesterol to Alzheimer’s disease. Credit: Department of Biochemistry and Biophysics Cholesterol tremendously increases the toxicity of a peptide implicated in Alzheimer’s progression, according to research by scientists in the Department of Biochemistry and Biophysics in Texas A&M’s College of Agriculture and Life...

Long COVID linked to lower brain oxygen levels, cognitive problems and psychiatric symptoms
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Long COVID linked to lower brain oxygen levels, cognitive problems and psychiatric symptoms

by University of Waterloo Oxygenated hemoglobin (Hbo) concentration location of Optode 9. Credit: Brain, Behavior, & Immunity – Health (2023). DOI: 10.1016/j.bbih.2023.100595 Long COVID is associated with reduced brain oxygen levels, worse performance on cognitive tests and increased psychiatric symptoms such as depression and anxiety, according to new research studying the impacts of the disease. Researchers from the University of...

Artificial intelligence improves colonoscopy accuracy
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Artificial intelligence improves colonoscopy accuracy

by Sharon Theimer, Mayo Clinic Credit: Shutterstock James East, M.D., spends his days skillfully examining people’s colons, searching for and snaring away suspicious polyps that might one day turn into cancer. A gastroenterologist at Mayo Clinic Healthcare in London, he says the ability to identify cancer risks and eliminate them on the spot during a...

A possible way to prevent or treat lung damage associated with long COVID
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A possible way to prevent or treat lung damage associated with long COVID

by Bob Yirka, Medical Xpress Mice in transition to COVID lung fibrosis and mice treated with anti-CD47/anti-IL-6 demonstrate improved fibrosis. (A) H&E and trichrome demonstrating lung histology after anti-CD47/anti-IL-6 treatment in mice in transition to COVID fibrosis. (Scale bar, 100 µm.) (B) Hydroxyproline assay calculated less extent of collagen accumulation. (C) Representative immunofluorescence images of...

Researchers uncover how gene that increases heart disease risk works
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Researchers uncover how gene that increases heart disease risk works

by Murdoch Children’s Research Institute Graphical representation of the findings from this study. Graphical summary of key findings from this study of sarcomere disorganization and SQSTM1 and MYOM1 mislocalization in ALPK3mut hPSC CMs. Credit: Nature Cardiovascular Research (2023). DOI: 10.1038/s44161-023-00219-9 Researchers have discovered how a gene that increases the risk of developing genetic heart disease functions, paving the way for new...

New purification method could make protein drugs cheaper
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New purification method could make protein drugs cheaper

by Anne Trafton, Massachusetts Institute of Technology A microfluidic device was designed to combine protein solution with nanoparticles and then form thousands of tiny, identical droplets. Inside each of these droplets, the proteins interact with the nanoparticles, which help them to form protein crystals. Credit: Massachusetts Institute of Technology One of the most expensive steps in...