by University College London Credit: Unsplash/CC0 Public Domain Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma. Previous studies have suggested a possible link between head injury and increased rates of brain...
by King’s College London UCART19 cellular kinetics and correlation with clinical response. A, Graphical representation of UCART19 kinetic profile in PB of patients with B-ALL in the CALM study. B, Individual UCART19 kinetic profiles of adult patients with B-ALL by best overall response (BOR). C, From left to right: UCART19 AUC0-28 (AUC between day 0 and...
by University of Virginia FTO in macrophage VEGFA release and choroidal neovascularization. a Quantification of Vegfa, m6A methyltransferase (Mettl3, Mettl4), demethylase (Fto) mRNA levels in pooled eye tissues (n = 3) of control, naive (no laser treated) mice (Ctrl) or mice following laser injury (choroidal neovascularization, CNV, day 3 after laser injury). b, c Immunofluorescent staining of...
by University of Queensland (A–E) Live imaging of non-stimulated and stimulated (30 min, 20 Hz) Drosophila larval NMJ boutons expressing Atg8mCherry at endogenous levels in the absence of Ca2+ (A and A′), presence of Ca2+ (B and B′), presence of EGTA-AM (no Ca2+ in the buffer) (C), and presence of DMSO plus Ca2+ (D). Fluorescence intensities shown using scale (0–1292 gray value)...
by Michael Addelman, University of Manchester Credit: Pixabay/CC0 Public Domain Researchers will tell an international conference today (Feb. 24) that an investigational gene therapy for Sanfilippo syndrome—which leads to a form of childhood dementia—has shown promising early results in a proof-of-concept study. It found four out of five patients diagnosed with Sanfilippo have continued to gain cognitive skills...
Published Feb. 22, 2023 Elise Reuter Reporter The new Apple Watch Ultra is displayed during an Apple special event on Sept. 7, 2022, in Cupertino, California. Justin Sullivan via Getty Images Apple has developed a proof-of-concept device for needle-free blood glucose monitoring, Bloomberg reported on Wednesday, citing people familiar with the matter. Apple’s device would use light...
by University de Liege Immunostaining AM ILC2. Credit: P.Loos and A.Hego-ULiège A study conducted by researchers at the University of Liège on group 2 innate lymphoid cells (or ILC2s) shows that the functional reprogramming of these cells following their exposure to viruses allows our body to react differently to exposure to certain respiratory allergens. This study is...
by Hokkaido University Photograph of the semitransparent hydrogel used in this study. Credit: Satoshi Tanikawa et al, Scientific Reports, February 14, 2023. DOI: 10.1038/s41598-023-28870-z Synthetic hydrogels were shown to provide an effective scaffold for neuronal tissue growth in areas of brain damage, providing a possible approach for brain tissue reconstruction. While growing brains may sound like...
by Universität Münster UB-modified lysines reside in functional domains of the IAV polymerase. a, b 3D structural models of a WSN-adapted heterotrimeric IAV polymerase bound to vRNA (adapted from PDB: 4WSB; a) or cRNA (adapted from PDB: 5EPI; b) created by comparative homology modeling. Positions of lysines with diglycyl remnants are depicted in violet (PB2,...
FEBRUARY 23RD, 2023 CONN HASTINGS MEDICINE, PUBLIC HEALTH Researchers at the Garvan Institute of Medical Research in Australia have developed a new generation of antibodies to treat COVID-19. So far, the antibodies have been shown to neutralize several of the viral variants behind COVID-19, and the researchers hope that they will form an effective treatment for at-risk patients. Previously developed...
