By Dr. Liji Thomas, MD Jun 16 2023 Reviewed by Lily Ramsey, LLM Aging is a physiological function change affecting life at all scales, from cell to organ level. The drivers of this alteration are still largely unknown. However, shifts in the concentration of various molecules occur with aging. In this respect, an interesting new...
EXERCISE SOON AFTER CONCUSSION MAY SPEED RECOVERY
The study adds to the growing body of science that suggests that “cocoon therapy”—bed rest in the dark with minimal mental stimulation after concussion—isn’t good for patients. Instead, when done under the guidance of a trained clinician, exercise is preferable, says Landon Lempke, a research fellow with appointments at the University of Michigan Concussion Center and the Exercise and...
Brain modelling used to identify necessary circuits of consciousness
HUMAN BRAIN PROJECT IMAGE: RESPONSE DIFFERENCES IN BRAIN CIRCUITS WHEN BROADCASTING (TOP ROW) OR RECEIVING SIGNALS (BOTTOM ROW). LEFT: HEALTHY CONTROLS; MIDDLE: UNRESPONSIVE WAKEFULNESS; RIGHT: MINIMALLY CONSCIOUS CREDIT: R. PANDA Researchers of the Human Brain Project have used a model-based approach to identify the brain circuits implicated in consciousness. The results of the study, a...
Astrocyte processing of serotonin shown to regulate olfactory perception
by Baylor College of Medicine Credit: Unsplash/CC0 Public Domain To enjoy the scent of morning coffee and freshly baked cookies or to perceive the warning smell of something burning, the brain needs two types of cells, neurons and astrocytes, to work closely with each other. Research has shown a great deal of the changes that occur in neurons...
Latin Americans with greater Native American ancestry may be more susceptible to liver failure
by University College London EF CLIF infographic showing results of the ACLARA study in Latin America. Credit: EF CLIF Differences in the percentage of Native American ancestry in Latin American people are linked with the chances of them developing severe liver failure and associated high risk of short-term mortality, a study co-authored by UCL has found....
Endocrine-disrupting chemicals may raise risk of cognitive disorders in future generations, animal study finds
by The Endocrine Society PCB warning label affixed to a railroad signal power supply transformer dating from the 1930’s at CP-SLOPE interlocking, west of Altoona, PA on the Norfolk Southern Pittsburgh Line. Credit: Sturmovik/Wikipedia Adverse cognitive effects linked to polychlorinated biphenyls (PCBs) exposure, a type of endocrine-disrupting chemical (EDC), have the potential to be passed down...
Study shows reactivation of beta-like cells in the pancreas to produce insuli
by Baker Heart & Diabetes Institute Schematic organization of the exocrine and endocrine compartments in the human pancreas featuring the ductal epithelial cells which are hypothesized to contain progenitor cells capable of regeneration upon exposure to EZH2 inhibitors (EZH2i). Credit: Clinical Epigenetics (2023). DOI: 10.1186/s13148-023-01491-z A proof-of-concept study demonstrates that ductal cells derived from the human pancreas...
Researchers gain structural insights into the immune modulator Siglec-15 and its interaction with T cells
by CIC bioGUNE a Cartoon and surface representation of two views of the crystal structure of Siglec-15 in complex with anti-Siglec-15 5G12 Fab. 5G12 is composed of a heavy chain (HC) (in orange) and a light chain (LC) (in yellow). The variable (VH and VL) region of 5G12 Fab binds to the V-set domain of...
Early intervention for psoriasis with guselkumab tied to complete response
by Lori Solomon Guselkumab is consistently effective across subpopulations for the treatment of moderate-to-severe plaque psoriasis, according to a study published June 1 in the Journal of the European Academy of Dermatology & Venereology. Knut Schäkel, M.D., from Heidelberg University Hospital in Germany, and colleagues evaluated the impact of early disease intervention on clinical responses following...
New study gives clues on why exercise helps with inflammation
YORK UNIVERSITY TORONTO, CANADA, June 15, 2023 – Researchers have long known that moderate exercise has a beneficial impact on the body’s response to inflammation, but what’s been less understood is why. New research coming out of York University done on a mouse model suggests that the answers may lie at the production level of macrophages — white blood cells responsible for killing off...