UNIVERSITY OF CALIFORNIA – LOS ANGELES HEALTH SCIENCES SUMMARYTreating a mouse model of multiple sclerosis with the pregnancy hormone estriol reversed the breakdown of myelin in the brain’s cortex, a key region affected in multiple sclerosis, according to a new UCLA Health study. BACKGROUNDIn multiple sclerosis, inflammation spurs the immune system to strip away the...
Month: <span>June 2023</span>
Post
New taste and smell test could diagnose Alzheimer’s long before memory loss starts
by University of Warwick Credit: Pixabay/CC0 Public Domain A simple smell and taste test could revolutionize diagnosis of Alzheimer’s—long before symptoms of memory loss even arise. Scientists are working on a ground-breaking medical screening for the disease which could also improve treatment options. The research is based on growing evidence that people with Alzheimer’s can lose their sense of smell and...
Post
Further hope for base-edited T-cell therapy to treat resistant leukemia
by University College London Credit: Pixabay/CC0 Public Domain Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a “bench-to-bedside” collaboration between University College London (UCL) and Great Ormond Street Hospital for Children (GOSH). The data from the NHS clinical trial, published in The New England Journal of Medicine, shows...
Post
A plant-based, oral delivery of insulin regulates blood sugar levels similar to natural insulin: Study
by Lauren Rebecca Thacker, University of Pennsylvania Graphical Abstract: Current and future insulin drug delivery methods and percentage global usage: (A) Subcutaneous insulin injections: Syringes and vials—9.6%. (B) Transdermal Insulin Pen—85.6%. (C) Implantable insulin pump—< 5% (D) Insulin Inhalers—<5% (E) Transdermal insulin Patches <5% people. (F) Oral Delivery using micro or nano particles—in development. (G) Oral...
Post
Inflammatory bowel disease linked to increased risk of stroke
by American Academy of Neurology Credit: CC0 Public Domain People with inflammatory bowel disease (IBD) are more likely to have a stroke than people without the disease, according to a study published in Neurology. The study does not prove that IBD causes stroke; it only shows an association. Inflammatory bowel disease causes chronic inflammation of the intestines....
Post
Serotonin booster leads to increased functional brain connectivity, shows study
by Elsevier This figure shows that the healthy participants who received prucalopride had greater functional connectivity between key cognitive regions (the posterior / anterior cingulate cortices) and a major cognitive network (the central executive network). That is, they appeared to be strengthening their connectivity within cognitive networks. Credit: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (2023). DOI: 10.1016/j.bpsc.2023.03.014 Cognitive...
Post
Merck steps into NASH space with early data for its GLP-1/glucagon receptor co-agonistb
Katherine Lewin News Reporter Merck is teasing data for efinopegdutide, a GLP-1/glucagon receptor co-agonist, in nonalcoholic steatohepatitis (NASH) and how it compares to Novo Nordisk’s semaglutide, with plans to share more detailed data from the study at the European Association for the Study of the Liver’s annual meeting later this month. Merck plans to use...
Post
Losing weight and keeping it off involves more than willpower
By Bronwyn Thompson June 12, 2023 Your brain chemistry may be making it that much harder to lose weight Depositphotos Nearly 42% of adults across the US have obesity, according to the most recent reporting from the Centers for Disease Control and Prevention. And while size and poor health outcomes aren’t always connected, adults with...
Post
World’s first illustration of the molecular machinery that makes cilia beat
Peer-Reviewed Publication UNIVERSITY COLLEGE LONDON IMAGE: ILLUSTRATION OF HUMAN CILIA AXONEME REPEAT The first image of the structures that power human cilia – the tiny, hairlike projections that line our airways – has been produced by a team involving UCL researchers and could lead to much-needed treatments for people with rare cilial diseases. The study,...
Post
Researchers unlock predictive biomarkers for common hip disorder
Discovery has the potential to aid in early diagnosis and treatment of hip dysplasiaP UNIVERSITY OF MISSOURI-COLUMBIA Researchers from the University of Missouri School of Medicine have developed panels of protein biomarkers present in teens and young adults that distinguish individuals with healthy hips from those with developmental dysplasia of the hip, also known as...