by Julia Evangelou Strait, Washington University in St. Louis Thin slice of a human prostate tumor. The dark staining throughout reveals the presence of histone acetylation promoting cholesterol production. Cholesterol is required to make testosterone, which fuels tumor growth. Credit: Nupam Mahajan/School of Medicine A new study in mice, led by researchers at Washington University School...
by Christoph Elhardt, ETH Zurich The subjects first focus on the cross before comparing the inclination of the Gabor patches in two rounds. Credit: Schaffner et al., 2023 Are our senses there to provide us with the most complete representation of the world, or do they serve our survival? For a long time, the former was...
by Laurel Hamers, University of Oregon An often-overlooked communication strategy for neurons might be more prevalent than previously believed. New research from biology professor Adam Miller’s lab in the UO’s College of Arts and Sciences illuminates the importance of neuron-to-neuron communication via direct electrical signaling, instead of the usual chemical messengers sent between cells. The team...
by Helmholtz Association of German Research Centres In the cell culture experiment: Disrupted motor neurons of ALS patients are stimulated with magnetic pulses (coil top left) and regain their original performance. Motor neurons in healthy individuals send signals to the skeletal muscles. ALS, however, is currently an incurable, neurodegenerative disease in which motor neurons are severely...
by Impact Journals LLC Figure 6: LP-284 is selectively lethal in cells with TC-NER deficiency. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28454 A new research paper titled “LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin’s lymphoma models and in cells deficient in DNA damage repair” has been published in Oncotarget. Despite advances in therapies treating non-Hodgkin’s lymphoma (NHL),...
by University of California, San Francisco Credit: CC0 Public Domain A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug’s effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder. The researchers, led by physician-scientist Ari...
by Lancet Credit: Pixabay/CC0 Public Domain The VLA1553 vaccine candidate for chikungunya disease was generally well tolerated and produced an immune response in 99% (263/266) of participants, according to a phase 3 randomized controlled trial published in The Lancet. Because the study, VLA1553-301, was not conducted in regions where chikungunya is endemic, researchers were unable to investigate whether the vaccine protects against subsequent...
by Taylor & Francis Space-filling model of the Cholesterol molecule. Credit: RedAndr/Wikipedia Increased levels of lipoprotein(a), a variant of “bad cholesterol” in the bloodstream, are a risk factor for recurrent coronary heart disease (CHD) in people aged 60 or over, according to the results of a new study which tracked the issue over the course of...
by Jules Bernstein, University of California – Riverside Credit: Pixabay/CC0 Public Domain A groundbreaking machine-learning study has unmasked the best drug combinations to prevent COVID-19 from coming back after an initial infection. It turns out these combos are not the same for every patient. Using real-world data from a hospital in China, the UC Riverside-led study...
by Cait Cullen, IOP Publishing In situ bioprinting could allow for the direct synthesis of personalized tissues and organs within the body, potentially paving the future of regenerative medicine and organ transplantation. Credit: Pagan et al. In situ bioprinting, which involves 3D printing biocompatible structures and tissues directly within the body, has seen steady progress over...
