by Linköping University Credit: CC0 Public Domain Women suffering from the autoimmune disease multiple sclerosis temporarily get much better when pregnant. Researchers have now identified the beneficial changes naturally occurring in the immune system during pregnancy. The findings, published in Journal of Neuroinflammation, may pave the way to new treatments. Pregnancy is a very special condition from an immunological...
Researchers create new model of lung mesenchymal cells
by Boston University School of Medicine In vitro differentiation of iPSCs toward the lung mesenchyme lineage through a mesodermal progenitor. a Schematic of the Tbx4 lung enhancer reporter/tracer (LER) line, and image of an E10 embryo (dox from E6.5 to E10). Scale bar = 0.5 mm. Created with BioRender.com. b Directed differentiation of iPSCs into lung mesenchyme through a mesodermal progenitor. cSFDM = complete serum-free differentiation medium,...
Neuron Support Squad: Perlecan Protein Key to Synaptic Durability
Summary: A new study discovered the critical role that Perlecan, a protein, plays in maintaining the structural integrity of neurons, particularly the long branches called axons. The study found that in the absence of Perlecan, axons in Drosophila fruit flies broke apart during development, leading to the death of their connections or synapses. Perlecan aids in...
Study explains why light-to-moderate alcohol consumption may be linked to lower cardiovascular risk
Reviewed by Lily Ramsey, LLM Jun 12 2023 A new study led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, offers an explanation for why light-to-moderate alcohol consumption may be associated with lower risk of heart disease. For the first time, researchers found that alcohol, in light...
Taurine supplement makes animals live longer — what it means for people is unclear
Myriam Vidal Valero Previous studies have explored taurine’s role in keeping the body healthy. Credit: Christine Whitehead/Alamy Ageing mice, worms and monkeys can live longer or healthier lives when fed large amounts of taurine, a common ingredient in health supplements and energy drinks, a study suggests. Researchers showed that levels of the naturally occurring amino acid...
Fine-tuning cell mechanics stimulates hair growth: Study
Reviewed by Danielle Ellis, B.Sc. Jun 6 2023 Just as people’s joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study. But if the hair follicle’s stem cells...
Engineered White Blood Cells Eliminate Cancer
Posted on June 12, 2023 Author Melissa Pappas “Macrophages killing cancer cell” photographed by Susan Arnold. By silencing the molecular pathway that prevents macrophages from attacking our own cells, Penn Engineers have manipulated these white blood cells to eliminate solid tumors. Cancer remains one of the leading causes of death in the U.S. at over 600,000 deaths...
40 Hz Vibrations Reduce Alzheimer’s Pathology, Symptoms in Mouse Models
Tactile stimulation improved motor performance in Alzheimer’s mice models, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows. Evidence that noninvasive sensory stimulation of 40 Hz gamma frequency brain rhythms can reduce Alzheimer’s disease pathology and symptoms, already shown with light and sound by multiple research groups in mice and humans, now...
Bacteria With a Taste for Inflammatory Compound Could Protect Against Heart Disease
Some bacteria in the guts of humans and mice may help control plaque buildup in arteries, the leading cause of cardiovascular disease, by gobbling up a group of inflammatory chemicals before they can circulate. New research from the University of Wisconsin–Madison and collaborators worldwide identified microbes able to break down uric acid in the low-oxygen environment of the...
Chronic exposure to lead, cadmium and arsenic increases risk of cardiovascular disease
AMERICAN HEART ASSOCIATION Statement Highlights: Around the world, most people are regularly exposed to low or moderate levels of lead, cadmium and arsenic in the environment, increasing risk of coronary artery disease, stroke and peripheral artery disease, according to a new American Heart Association statement. These metals, considered contaminant metals, have no function in the...