by American Association for Cancer Research Credit: CC0 Public Domain First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically associated with poor outcomes, according to results recently published in Clinical Cancer Research. Patients with high-risk CLL, defined by...
by Wiley Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domain New research reveals that the level of fat within the body’s muscle—or muscle adiposity—may indicate a person’s likelihood of experiencing cognitive decline as they age. In the study published in the Journal of the American Geriatrics Society, 5-year increase in fat stored in the...
by Justin Jackson, Medical Xpress Machine Learning Indices, SPARE-AD and SPARE-BA, as a Function of Age. A, there was no significant difference observed between EDIC participants (blue) and controls without diabetes (orange). In panel B, EDIC participants showed a significant increase in predicted brain age (SPARE-BA) demonstrating more advanced brain aging patterns. SPARE-AD indicates spatial...
by National Institutes of Health Study participants scanned themselves with ultrasound at home as part of a study aimed at uncovering whether patients could produce high-quality diagnostic images outside of the clinic. Credit: Duggan et al., CC BY 4.0 license One day, the ultrasound equipment that health care professionals use for essential diagnostic imaging may no longer be...
by University of Barcelona Optogenetic stimulation of M2 cortex terminals in the SC evoked similar electrophysiological responses in WT and HD mice. A, Schematic representation of AAV-CamKII-ChR2-YFP construct injection at M2 cortex. B, Representative MEA location in coronal slices containing the SC with axons from M2 cortex expressing ChR2. C, Amplitude of fPSC triggered by increasing...
by Monash University Credit: Unsplash/CC0 Public Domain A best treatment pathway has been identified for people with multiple sclerosis (MS) whose current medication puts them at risk of a serious brain infection. MS patients who take the highly effective drug natalizumab are monitored regularly for their risk of developing a potentially deadly brain infection known as...
By Elaine Chen June 5, 2023 ADOBE GLP-1s, a class of drugs including Ozempic and Wegovy that have become widely popular for treating obesity and diabetes, are also being studied for NASH, a form of fatty liver disease. But a new small study suggests GLP-1s may not dominate the disease area as they have others. Akero Therapeutics tested...
High-profile coverage of the off-label use of Ozempic, a GLP-1 agonist, for weight loss, has meant that the type 2 diabetes drug has received a lot of bad press. As more studies into the long-term impact of this group of drugs are published, other potential benefits of the drug are emerging. Glucagon-like peptide-1 (GLP-1) agonist...
By Ben Coxworth June 02, 2023 There is currently no word on when human trials of the PAINT pen may commenceAdapted from ACS Applied Materials & Interfaces, 2023, DOI: 10.1021/acsami.3c03630VIEW 1 IMAGES Most wound dressings simply cover the injury and perhaps also kill harmful bacteria. The PAINT system goes much further, as it incorporates a...
By Paul McClure June 04, 2023 Researchers have used microparticle therapy to reverse the breakdown of the nerve cells’ protective sheath in mice with multiple sclerosisVIEW 1 IMAGES A new study using microparticle therapy to boost the number of ‘good’ immune cells has reversed the nerve cell damage in mice with multiple sclerosis-like symptoms and...
