THE HOSPITAL FOR SICK CHILDREN Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide. While the human genome comprises coding and non-coding...
Month: <span>June 2023</span>
Post
A lung injury therapy derived from adult skin cells
OHIO STATE UNIVERSITY COLUMBUS, Ohio – Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma. Researchers conducted experiments in cell cultures and mice to demonstrate the therapeutic potential of these nanoparticles, which...
Post
Swarming microrobots self-organize into diverse patterns
CORNELL UNIVERSITY ITHACA, N.Y. — A research collaboration between Cornell and the Max Planck Institute for Intelligent Systems has found an efficient way to expand the collective behavior of swarming microrobots: Mixing different sizes of the micron-scale ‘bots enables them to self-organize into diverse patterns that can be manipulated when a magnetic field is applied. The technique even...
Post
Magnetic microrobots with folate targeting for drug delivery
BEIJING INSTITUTE OF TECHNOLOGY PRESS CO., LTD IMAGE: THE INTRODUCTION OF FA IMPROVED THE TUMOR TARGETING ABILITY OF THE MICROROBOTS, WHICH CAN BE MANIPULATED BY MAGNETIC FIELDS, PRODUCING AN OBVIOUS ANTICANCER EFFECT. CREDIT: CYBORG AND BIONIC SYSTEMS The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this,...
Post
Researchers use new deep learning approach to enable analysis of electrocardiograms as language
by The Mount Sinai Hospital HeartBEiT is much more precise at highlighting areas of interest, in this case for diagnosing heart attacks (myocardial infarction). Credit: Augmented Intelligence in Medicine and Science Laboratory at the Icahn School of Medicine at Mount Sinai Mount Sinai researchers have developed an innovative artificial intelligence (AI) model for electrocardiogram (ECG) analysis that allows...
Post
Antidepressant Psychedelics With No Hallucinations May Finally Be Possible
HEALTH 06 June 2023 By FELICITY NELSON (Jun/Getty Images) Researchers have recently shown that separate mechanisms drive the hallucinogenic and antidepressant effects of psychedelics like LSD and psilocin, potentially paving the way to use these ‘party drugs’ as treatments that don’t trigger psychedelic trips. “The antidepressant and plasticity-promoting effects of psychedelics may be dissociable from their hallucinogenic effects,” the researchers write...
Post
In a “landmark” phase III trial, a skin patch to combat peanut allergies in children under the age of 4 has shown to be safe and more effective than placebo
By Andy Corbley Jun 5, 2023 In a “landmark” phase III trial, a skin patch to combat peanut allergies in children under the age of 4 has shown to be safe and more effective than placebo. The patch works like exposure therapy, slowly training the toddlers’ bodies to tolerate proteins in peanuts that may cause...
Post
Nanobiotics: AI for discovering where and how nanoparticles bind with proteins
by Kate McAlpine, University of Michigan The new computer model, NeCLAS, predicts that a nanoparticle, shown as a set of yellow balls attached by netting, fits neatly around a very specific protrusion on a protein, marked in blue. The binding site is confirmed by experiments. These kinds of nanoparticles, called molecular tweezers, can be used to...
Post
Nanozyme hydrogel: A breakthrough solution for Candida vaginitis treatment
by Nanjing University Schematic illustrating Candida vaginitis microenvironment and FeLab-enabled microenvironmental regulation for Candida vaginitis therapy. Left: Candida vaginitis microenvironment characterized with hyperproliferating C. albicans, elevated vaginal pH, imbalance of vaginal microbiota, and damaged vaginal mucosal cells. Right: FeLab-enabled microenvironmental regulation for Candida vaginitis therapy. The HAase secreted by C. albicans and bacteria can degrade HA,...
Post
Tirzepatide has unique activity to stimulate insulin secretion, suggests study
by Duke University Medical Center Credit: CC0 Public Domain Tirzepatide, a drug approved for diabetes and on the fast track for approval as a weight loss therapy, works through a unique ability to activate two different mechanisms the body uses to control insulin secretion and energy balance, Duke Health researchers report. The finding reported June 5 in the...