EUROPEAN ALLIANCE OF ASSOCIATIONS FOR RHEUMATOLOGY (EULAR) “This evidence suggests that inflammation in PsA is not limited to skin and joints, but also involves the cardiovascular system”, says Nienke Kleinrensink, lead author on the abstract shared in a session on Comorbidities in RMD at the 2023 EULAR congress in Milan, Italy. The new finding is based on...
Month: <span>June 2023</span>
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Exploring the role of AI in early AI
EUROPEAN ALLIANCE OF ASSOCIATIONS FOR RHEUMATOLOGY (EULAR) Early inflammatory arthritis is often undifferentiated, but it may develop into established RA or another arthropathy.1 Alternatively, it may resolve spontaneously, or remain undifferentiated for indefinite periods. Erosion is a key prognostic factor which can be detected with magnetic resonance imaging (MRI).2 In addition, MRI allows direct visualization...
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Lung infection caused by a little-known bacterium may be less transmissible than thought
by Illima Loomis, Harvard Medical School Credit: Pixabay/CC0 Public Domain A little-known bacterium—a distant cousin of the microbes that cause tuberculosis and leprosy—is emerging as a public health threat capable of causing severe lung infections among vulnerable populations, those with compromised immunity or reduced lung function. Previous research had found that various strains of the bacterium Mycobacterium abscessus...
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Computational method uncovers the effects of mutations in the noncoding genome
by Brigham and Women’s Hospital Graphical abstract. Credit: Cell Genomics (2023). DOI: 10.1016/j.xgen.2023.100327 Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation. Mutations in the noncoding genome often trigger trait changes that cause disease or disability by altering gene expression. However, it can be hard...
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New study finds that the shape of the brain influences the way it works
by Monash University Credit: CC0 Public Domain For over a century, researchers have thought that the patterns of brain activity that define our experiences, hopes and dreams are determined by how different brain regions communicate with each other through a complex web of trillions of cellular connections. Now, a study led by from researchers at Monash University’s Turner Institute for...
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Study finds how a genetic variant raises diabetes risk through an unexpected mechanism
by Andrea Tamayo, Broad Institute of MIT and Harvard Healthy fat cells, or adipocytes, with numerous fat deposits (green). Credit: Phil Kubitz, Claussnitzer lab Researchers have uncovered the mechanism through which a single DNA base change dramatically raises the risk of a subform of type 2 diabetes (T2D) called metabolically obese normal weight (MONW). This genetic variant,...
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Beating seizures by jamming the cellular circuitry
by Levi Gadye, University of California, San Francisco The EMC complex was first identified by UCSF scientists in 2009. Here, the EMC (red outline) is shown holding several parts, or subunits, of a voltage gated calcium channel (green outline) as the channel is being assembled. Credit: Dan Minor Research at UC San Francisco has shown for the...
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Gut microbiome changes linked to precancerous colon polyps
by Liz Murphy, Massachusetts General Hospital Graphical abstract. Credit: Cell Host & Microbe (2023). DOI: 10.1016/j.chom.2023.04.007 A new study by investigators from Mass General Brigham has linked certain types of gut bacteria to the development of precancerous colon polyps. Their results are published in Cell Host & Microbe. “Researchers have done a lot of work to understand the relationship between...
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Why targeting BTLA, a novel checkpoint receptor, may be key to treating an overactive immune system
Over the last decade, antibodies that block extracellular receptors on our immune cells have redefined the treatment approach for certain cancers. Now, all eyes are on how using the opposite approach may help treat autoimmune and inflammatory diseases. Our immune system is an intricate web of checks and balances meant to detect, identify, and destroy...
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Color-changing material indicates when medications get too warm
by American Chemical Society Appearing green on a vial lid (left), this structural color material becomes colorless (right) when warmed. Credit: Adapted from ACS Nano 2023, DOI: 10.1021/acsnano.3c00467 Some foods and medicines, such as many COVID-19 vaccines, must be kept cold. As a step toward a robust, stable technique that could indicate when these products exceed safe limits, researchers in ACS...