by Chris Barncard, University of Wisconsin-Madison Graphical abstract. Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.10.014 Removing a gene that manages stress within insulin-producing beta cells draws helpful attention from the immune system, protecting mice predisposed to type 1 diabetes from developing the disease, a new University of Wisconsin–Madison study shows. The study also found that changes discovered...
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Initial patient dosed in Phase 2a clinical trial evaluating first-in-class human milk-based therapy in patients undergoing stem cell transplantation for blood cancers
Seeking strategic partners for continued clinical development of PBCLN-010 with PBCLN-014, a lead investigational therapy comprising human milk sugars and gut bacteria found in nursing infants Business Announcement PROLACTA BIOSCIENCE DUARTE, Calif., Nov. 10, 2023 – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient...
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Brazzein and monellin: Safe alternatives to sugar, new research confirms
By Pooja Toshniwal PahariaNov 10 2023Reviewed by Lily Ramsey, LLM In a recent study published in Foods, researchers comprehensively performed toxicity assessments of monellin and brazzein, recombinant naturally sweet proteins produced by yeasts. Study: Sweet-Tasting Natural Proteins Brazzein and Monellin: Safe Sugar Substitutes for the Food Industry. Image Credit: John B Hewitt/Shutterstock.comBackground Monellin and brazzein,...
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BRUSHLENS’ SMARTPHONE CASE BOOSTS TOUCHSCREEN ACCESSIBILITY
OCTOBER 27TH, 2023POSTED BY KATE MCALPINE-MICHIGAN A new smartphone case could soon help people with visual impairments, tremors, and spasms use touchscreens independently. The case, dubbed BrushLens, could let users perceive, locate, and tap buttons and keys on the touchscreen menus now ubiquitous in restaurant kiosks, ATM machines, and other public terminals. “So many technologies around...
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SKIN PATCH PREDICTS ANAPHYLAXIS IN FOOD ALLERGY TEST
NOVEMBER 9TH, 2023POSTED BY U. MICHIGAN (Credit: Sketch/Unsplash) Measuring water loss from the skin can predict anaphylaxis during oral food challenges before it becomes clinically evident, say researchers. Anaphylaxis—a severe allergic reaction that may include a skin rash, nausea, vomiting, difficulty breathing, and shock—from a food allergy sends 200,000 people to the emergency room annually in the...
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Trial generates promising results for obinutuzumab in patients with lupus nephritis
Peer-Reviewed Publication WILEY In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab—an antibody that targets a protein expressed on certain immune cells—was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus. In...
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Having more diverse gut bacteria can protect against diarrheal disease, study finds
by University of East Anglia Credit: Unsplash/CC0 Public Domain The severity of a diarrheal disease could be down to the bacteria in your gut, according to new research from the University of East Anglia. Cryptosporidiosis is responsible for over 100,000 deaths annually, predominantly in children under five. It also affects animals, and a new study published...
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Lack of friend or family visits is associated with increased risk of dying
by BioMed Central Credit: CC0 Public Domain Never being visited by friends or family is associated with an increased risk of dying, according to a study published in BMC Medicine. The authors suggest that their findings could be used to help identify patients at a higher risk of dying due to social factors, and to develop...
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Cardiologists reveal new heart disease risk calculator
by American Heart Association Credit: Unsplash/CC0 Public Domain A new calculator estimates a person’s risk for cardiovascular disease (CVD) over the next 30 years by combining measures of cardiovascular, kidney and metabolic health for the first time, according to a new American Heart Association Scientific Statement published today in Circulation. An accompanying methods paper, published simultaneously...
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Standing BP Measures Improve Hypertension Diagnosis
Pauline Anderson November 08, 2023 TOPLINE: Obtaining standing office blood pressure (BP) measurements improves detection of hypertension, either alone or when added to a seated BP reading, results of a new study suggest. METHODOLOGY: TAKEAWAY: IN PRACTICE: The “excellent diagnostic performance” for standing BP measures revealed by the study “highlights that standing office BP has acceptable discriminative capabilities...