Karen H. Miga Evan E. Eichler DOI:https://doi.org/10.1016/j.ajhg.2023.09.011 SummaryAdvances in long-read sequencing and assembly now mean that individual labs can generate phased genomes that are more accurate and more contiguous than the original human reference genome. With declining costs and increasing democratization of technology, we suggest that complete genome assemblies, where both parental haplotypes are phased...
New antibodies neutralize resistant bacteria
Peer-Reviewed Publication UNIVERSITY OF COLOGNE CREDIT: CSSB/BIAO YUAN CRYO-ELECTRON MICROSCOPE RECONSTRUCTION OF THE BINDING OF A HUMAN ANTI-PCRV FAB ANTIBODY (YELLOW) TO A PCRV PENTAMER (BLUE) OF THE TYPE III SECRETION SYSTEM (T3SS) OF PSEUDOMONAS AERUGINOSA. THE ANTIBODY BINDING LEADS TO AN INHIBITION OF THE T3SS, WHICH IS AN IMPORTANT VIRULENCE FACTOR OF P. AERUGINOSA....
Clinical trial suggests fecal transplants may protect transplant patients against multi-drug-resistant organisms
by Bob Yirka , Medical Xpress Depth of coverage of metagenome reads from participant stool samples mapped to representative genomes from participants with detected conspecific strain replacement after FMT. (A) Depth of coverage for patients PM01, PM03, PM04, and PM07 show higher coverage depth for replacing strains after FMT. (B) Ratio of coverage depth for...
The role of the epigenome in cancer revealed in new study
by Julia Evangelou Strait, Washington University School of Medicine in St. Louis Schematic of the data generation and study design, showing the cancer types and sample types collected, the building, annotation and integration of the atlas, and the biological entities that were investigated. Credit: Nature (2023). DOI: 10.1038/s41586-023-06682-5 For decades, scientists have been sequencing the DNA...
Colorectal cancer: Aspirin found to activate protective genes
by Ludwig Maximilian University of Munich Salicylate suppresses viability and proliferation of CRC cells independent of p53. A Cell viability of HCT116 cells was determined by MTT assay after treatment with indicated concentrations of salicylate for 48 h. IC50 was determined using GraphPad Prism based on changes in viability. B Cell viability of non-transformed CCD-18-Co and HCEC-1CT...
Experimental COVID-19 vaccine provides mutation-resistant T cell protection in mice
by University of Wisconsin-Madison Brock Kingstad-Bakke, a scientist in the UW School of Veterinary Medicine. Credit: School of Veterinary Medicine A second line of defense—the immune system’s T cells—may offer protection from COVID-19 even when vaccine-induced antibodies no longer can, according to new research out of the University of Wisconsin School of Veterinary Medicine. The researchers...
Shared medical appointments increase patient engagement, finds research
by Kim Matthies, European School of Management and Technology (ESMT) Credit: SHVETS production from Pexels Research from ESMT Berlin finds that shared medical appointments increase engagement from patients as they ask more questions, make more comments, and exhibit higher levels of nonverbal engagement, providing greater value for other patients in the sessions. One-on-one service delivery...
Clinical trial suggests ALS drug effective for treating spinal cord injuries
by Laurie Fickman, University of Houston Riluzole trough and peak concentrations from Phase I and Phase II/III trials presented in waterfall plots. Credit: Journal of Neurotrauma (2023). DOI: 10.1089/neu.2022.0499 A small clinical trial with a pharmacokinetic sub-study, led by a pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for...
Only 30% of adults discuss pain relievers with doctors despite risk of raising blood pressure, finds poll
by Julia Kersey, American Heart Association Credit: CC0 Public Domain Only about 30% of U.S. adults have spoken with their health care professional about the adverse effects some over-the-counter (OTC) pain relievers can have on blood pressure, despite that fact that more than half of all adults in the country have elevated blood pressure, a leading...
Docetaxel use associated with significant reduction in prostate cancer death in very poor prognostic group
by Brigham and Women’s Hospital Credit: Unsplash/CC0 Public Domain Men with high-grade prostate cancer and low prostate-specific antigen (PSA) levels have a poor prognosis. The question remains as to whether the chemotherapy drug docetaxel, which increases survival in metastatic prostate cancer, can improve the cure rate in these patients. In a new study by investigators from...