by Medical University of South Carolina Paxillin localization during HSC activation. (A) HSCs were isolated, grown on glass coverslips for 7 days, and fixed. Paxillin was labeled at the specified time points as described in the Materials and Methods. DAPI was used to label nuclei. The boxes in row 3 of the panel illustrate magnified area in...
by Association for Professionals in Infection Control Credit: Unsplash/CC0 Public Domain A new study published today in the American Journal of Infection Control (AJIC) reveals that the use of doxycycline may help protect against Clostridioides difficile (C. diff) infection for some patients with pneumonia. Specifically, study authors found that for hospitalized patients with community-acquired pneumonia...
by Orlando Health Credit: Pixabay/CC0 Public Domain If you’ve ever seen a movie or TV show in which a character has a seizure, you probably have a fairly standard mental picture of someone falling to the ground in full body convulsions while foaming at the mouth. But that doesn’t necessarily reflect reality. A new national survey...
by Northwestern University The synthetic melanin is being applied to inflamed skin. Just under the surface of the skin are green free radicals, also known as ROS, or “reactive oxygen species.” Credit: Yu Chen, Northwestern University Imagine a skin cream that heals damage occurring throughout the day when your skin is exposed to sunlight or environmental...
by Physician’s Briefing Staff A new gene therapy for sickle cell disease has been deemed safe by a U.S. Food and Drug Administration advisory panel, paving the way for full approval by early December 2023. The FDA had already decided that the therapy, known as exagamglogene autotemcel (exa-cel), was effective. Developed by Vertex Pharmaceuticals of...
by University of Bath Dr Despina Moschou with LoCKAmp replaceable lab on chip printed circuit board. Credit: University of Bath A virus diagnosis device that gives lab-quality results within just three minutes has been invented by engineers at the University of Bath, who describe it as the “world’s fastest COVID test.” The prototype LoCKAmp device uses...
by Julius-Maximilians-Universität Würzburg a Adoptive co-transfer of WT (tdTomato+GFP+) and HIF-1α-deficient (tdTomato+) P14 T cells into C57BL/6 mice before chronic infection with LCMV clone 13 (LCMVCL13). 21 days post infection (d.p.i.), donor P14 WT and HIF-1α-deficient T cells were FACS sorted, barcoded, and multiplexed in a 1:1 ratio and subjected to single-cell RNA sequencing. Uniform manifold...
by Higher Education Press Manganese therapy enables the reversal of atherosclerotic plaque. Credit: Yawei Wang, Xin Feng, Wenjing Zhou, Runze Huang, Yating Hu, Hui Hui, Jie Tian, Xiao Wang, Xiao-Wei Chen Cardiovascular disease (CVD) continue to rank as the top killer in the modern world. This deadly disorder often starts with the buildup of lipid...
by University of Chicago Medical Center Credit: Cell Reports Medicine (2023). DOI: 10.1016/j.xcrm.2023.101261 Type 1 diabetes is an autoimmune disease that causes the body’s immune system to attack and destroy insulin-producing beta cells in the pancreas. Traditional management of type 1 diabetes has primarily involved replacing the missing insulin with injections which, though effective, can be...
by Marcus Neitzert, Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Credit: Cell (2023). DOI: 10.1016/j.cell.2023.10.001 Researchers at DZNE and Charité–Universitätsmedizin Berlin have pioneered a novel treatment for the most common autoimmune encephalitis. By reprogramming white blood cells to target and eliminate disease-causing cells, the approach offers a new level of precision and efficiency. The technique...
