by Virginia Commonwealth University KRB-456 inhibits the growth in vivo of orthotopic mt KRAS tumors derived from pancreatic cancer patients. Tumor biopsies from pancreatic cancer patient G160 were prepared and implanted orthotopically into NSG mice as described in Methods. On day 20 after implantation, mice were treated i.p. daily for 30 days with vehicle or 5mpk...
A protective mineral coating identified by University of Wisconsin–Madison biomedical engineering researchers could allow powerful messenger RNA therapeutics like COVID-19 vaccines to be stored at room temperature, making them more accessible to lower-resourced communities across the world.Professor William Murphy (pictured left) and collaborators in his lab, including Joshua Choe (right), have engineered a mineral coating...
Using lasers and a holographic two-photon microscope that can peer deep into the brain, scientists have identified and activated a small handful of cells among the hundreds of millions in a mouse’s amygdala, a part of the brain that helps govern behavior. An image grabbed from a video recording the activation of neurons in a...
Dr. Liji Thomas, MDBy Dr. Liji Thomas, MDDec 17 2023Reviewed by Benedette Cuffari, M.Sc. Previous research has shown that both childhood behavioral issues and poor mental health are highly associated with sleep disturbances; however, their relationship over time has been poorly studied. A recent study published in JAMA Network Open explores the natural history of...
PUBLISHED SUN, DEC 17 20238:00 AM EST In this article LLY+0.36 (+0.06%)After HoursNovo Nordisk A/S Wegovy brand semaglutide medication arranged at a pharmacy in Provo, Utah, US, on Monday, Nov. 27, 2023. Prescriptions of appetite suppressing GLP-1 weight-loss drugs skyrocketed 300% from 2020 to 2022. Photographer: George Frey/Bloomberg via Getty Images George Frey | Bloomberg...
by Delthia Ricks , Medical Xpress N6F11 suppresses the growth of human PDAC. (A) PANC1 cells were pretreated with DMSO or N6F11 (5 µM) for 12 hours. (B) MiaPACA2 cells were pretreated with DMSO or N6F11 (5 µM) for 12 hours. (C) Effects of N6F11 on the growth of 3D PANC1 tumor spheroids for increasing...
by University of Technology, Sydney UTS researcher tests DeWave technology. Credit: University of Technology Sydney In a world-first, researchers from the GrapheneX-UTS Human-centric Artificial Intelligence Centre at the University of Technology Sydney (UTS) have developed a portable, non-invasive system that can decode silent thoughts and turn them into text. The technology could aid communication for people...
Liz Scherer For women who are obese, daily life is wrought with landmines. Whether it’s the challenges of air travel because plane seats are too small, the need to shield themselves from the world’s discriminating eyes, or the great lengths many will go to achieve better health and the promise of longevity, navigating life as...
by University of Washington School of Medicine Credit: Pixabay/CC0 Public Domain In a clinical trial of patients with chronic kidney disease, an experimental drug significantly reduced albuminuria—albumin in urine, a sign of kidney damage—for 50% of participants. When the experimental drug was paired with a standard-care medication, 70% of participants reportedly experienced a significant reduction in...
Nancy A. Melville A high proportion of patients treated with the thyroid eye disease drug teprotumumab (Tepezza) report signs of hearing dysfunction after three to four infusions, with nearly half having symptoms that appear persistent, according to a single-center analysis. “Hearing loss is a concerning adverse event [of teprotumumab] and its mechanism, and reversibility should...
