by University of Massachusetts Amherst Credit: Unsplash/CC0 Public Domain While we often think of diseases as caused by foreign bodies—bacteria or viruses—there are hundreds of diseases affecting humans that result from errors in cellular production of proteins. A team of researchers led by the University of Massachusetts Amherst leveraged the power of cutting-edge technology, including an...
by Kate Richards, University of Toronto—Leslie Dan Faculty of Pharmacy A team of researchers based at the University of Toronto’s (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle, iso-A11B5C1, that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues. Credit: Steve Southon, University of Toronto A...
by Koen Stein, Vrije Universiteit Brussel Panx1-targeting nanobodies interact with the NLRP3 inflammatory cascade in acetaminophen-overdosed mice. a Overview of the NLRP3 signaling cascade in acetaminophen (APAP)-induced hepatotoxicity. Overdosing mice with APAP triggers oxidative metabolization catalyzed by cytochrome (CYP) P450 enzymes in hepatocytes. Associated-NAPQI formation causes necrosis, which triggers a Panx1-mediated inflammatory response in the...
by University of California, Irvine Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.10.036 Researchers at the University of California, Irvine, discovered a mechanism that controls the identity of stem cells. When this mechanism fails, embryonic stem cells revert back in time and become totipotent. When a cell becomes totipotent, this rare change enables the cells to differentiate into...
by Centre for Addiction and Mental Health Credit: Pixabay/CC0 Public Domain CAMH-led pre-clinical studies using a small molecule drug have shown promise as a potential new treatment for multiple sclerosis (MS). The results have been published in the journal Science Advances. Expanding on Dr. Fang Liu’s earlier work that identified a novel drug target for the...
by Nancy Clanton, The Atlanta Journal-Constitution Credit: Pixabay/CC0 Public Domain America’s Poison Centers reported nearly 3,000 calls this year involving the weight loss drug semaglutide—a 15-fold increase since 2019, according to CNN. Some of the people calling described symptoms related to accidental overdose. Those who needed to be hospitalized usually recovered once they received fluids...
by Werner Siefer, Paul Scherrer Institute Overview of our platform to study the chromatin organization of peripheral blood mononuclear cells in a tumor and proton therapy setting. Credit: npj Precision Oncology (2023). DOI: 10.1038/s41698-023-00484-8 The ability to detect a developing tumor at a very early stage and to closely monitor the success or failure of cancer...
by Tokyo Medical and Dental University PD-1+CD8+ T cells were activated rather than exhausted. PD-1+CD8+ T cells infiltrated muscle tissues. Affected muscles reacted to IFNγ, which could be produced from effector T cells, as a danger signal and then expressed PD-L1. Muscles countered PD-1+CD8+ T cell attacks through the enhancement of PD-L1 expression. Credit: Department of...
by World Health Organization Benefits versus harms of simulated screening approaches. a,b, Cervical cancer incidence reduction versus average lifetime number of pre-cancer treatment events (a) and number of additional pre-term delivery events due to pre-cancer treatments per cohort of 100,000 women (b) for each screening approach in women living with HIV. ASR, age-standardized rate; yrly,...
by European Synchrotron Radiation Facility The structure of the ACAD9-ECSIT_CTER complex (ECSIT in red). An international team of researchers, led by the ESRF, have elucidated the structure of the ACAD9-ECSIT_CTER complex, by using cryo-EM techniques. This complex is important in the correct functioning of the energy-producing machinery in mitochondria. Credit: ESRF/M. Soler López. Credit: ESRF/M. Soler...
