This review provides a comprehensive summary of the latest advancements in targeted therapies for lupus nephritis, discusses the forthcoming challenges, and proposes strategies to effectively overcome these obstaclesPeer-Reviewed Publication CACTUS COMMUNICATIONS SLE INVOLVES ABNORMAL ACTIVATION OF BOTH INNATE AND ADAPTIVE IMMUNE RESPONSES, LEADING TO SYSTEMIC IMMUNE DYSREGULATION AND RENAL IMPAIRMENT. THE COMPLEMENT SYSTEM’S DYSFUNCTION IMPEDES...
Month: <span>December 2023</span>
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Mechanics of Breast Cancer Metastasis Discovered, Offering Target for Treatment
The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. New research, led by Penn State, reveals for the first time the mechanics behind how breast cancer cells may invade healthy tissues. The U.S. National Science Foundation-supported discovery, showing that a motor protein called dynein powers the movement...
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TEENS MAINLY USE CANNABIS FOR TWO REASONS
POSTED BY LISA HOWARD-UC DAVIS “We know that earlier onset of cannabis use is associated with the likelihood of developing a cannabis use disorder,” says Nicole Schultz. “It is important we understand what variables contribute to their use so that we can develop effective strategies to intervene early.” (Credit: Getty Images) New research surveyed teens over a...
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Researchers show that hydrogen sulfide regulates the neural circuit for respiration
by University of Tsukuba Credit: Unsplash/CC0 Public Domain While commonly associated with the unpleasant odor of hot springs, hydrogen sulfide is naturally produced in the body. Despite its toxicity at higher concentrations, the lower concentrations generated internally are indispensable for life. Researchers from the University of Tsukuba have demonstrated the importance of hydrogen sulfide in the...
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New ‘dictionary’ of immune responses reveals far more complexity in the immune system than previously thought
by Allessandra DiCorato, Broad Institute of MIT and Harvard Cytokine production map by cell type. Credit: Nature (2023). DOI: 10.1038/s41586-023-06816-9 The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do. Cytokines are...
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FDA expected to approve first CRISPR gene-editing treatment, bringing hope to thousands with sickle cell disease
By Meg Tirrell, CNN Since Johnny Lubin got the exa-cel treatment in October 2021, “he’s been like a normal child,” his mother says. “It’s life-changing for us.”Courtesy JR Lubin and Fabienne DesirCNN — Before Johnny Lubin got a potentially life-changing experimental treatment at the age of 13, he recalls, he had one main concern. “I was...
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Changing levels of NOX4 protein could provide key to understanding fatty liver disease progression
by Monash University Credit: Pixabay/CC0 Public Domain The global rise in obesity and diabetes is leading to an epidemic in fatty liver disease affecting 20%–30% of the world’s population. Almost a third of people with fatty liver disease go on to develop an advanced form of the disease, known as non-alcoholic steatohepatitis (NASH) that can progress...
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Novel stem cell therapy using mRNA technology may stimulate natural repair in liver disease
by Boston Medical Center Graphical Abstract. Credit: Cell Stem Cell (2023). DOI: 10.1017/j.stem.2023.10.008 Mortality related to end stage liver disease is ranked as the 12th most common cause of death in the U.S. Liver transplantation remains the only treatment for end stage liver disease, but there is a critical shortage of organ donors, necessitating a dire...
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Study links back pain to a subtype of cells in spinal ‘shock absorbers’
by Cedars-Sinai Medical Center Credit: CC0 Public Domain A new Cedars-Sinai study might have cracked the mystery surrounding the cause of a specific type of back pain. Almost 40% of the adult population experiences low back pain due to degenerating disks in the spine, but medical science hasn’t understood exactly why the disks become painful. In...
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More than 1 in 3 women have lasting health problems after giving birth, finds study
by World Health Organization (WHO) Credit: Unsplash/CC0 Public Domain Every year, at least 40 million women are likely to experience a long-term health problem caused by childbirth, according to a new study published today in The Lancet Global Health. Part of a special series on maternal health, the study shows a high burden of postnatal...