By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.Allessandra DiCorato | Broad Institute Illustration of bacteria. Among ordered lines of bacteria, a single bacterium is highlighted in a circle, and a DNA strand can be seen withinCaption:Researchers...
Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway
Front Pharmacol. 2017; 8: 875.Published online 2017 Nov 28. doi: 10.3389/fphar.2017.00875PMCID: PMC5712354PMID: 29234282Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase PathwayGauhar Rehman,1 Muhammad Hamayun,2 Amjad Iqbal,3 Sumera Afzal Khan,4 Hamayoon Khan,5 Adeeb Shehzad,6 Abdul Latif Khan,7 Anwar Hussain,2 Ho-Youn Kim,8 Jamshaid Ahmad,4 Ayaz Ahmad,9 Abid Ali,1 and In-Jung...
No More Needles? Gates Foundation Funds Patch-Style Vaccine Technology
By Jennifer Rigby LONDON (Reuters) – The Bill & Melinda Gates Foundation has given $23.6 million to U.S.-based life science company Micron Biomedical to fund the first ever mass production of needle-free vaccine technology. The technology works by delivering the vaccine via dissolvable microneedles attached to the skin on a patch-like device. Global health experts...
AI Tool Perfect in Study of Inflammatory Diseases
Donavyn Coffey Artificial intelligence can distinguish overlapping inflammatory conditions with total accuracy, according to a new study presented (abstract 2040) on November 14 at the 2023 annual meeting of the American College of Rheumatology. Texas pediatricians faced a conundrum during the pandemic. Endemic typhus, a flea-borne tropical infection common to the region, is nearly indistinguishable...
Decoding cell fate: Key mechanism in stem cell switch identified
by Institute of Molecular Biotechnology of the Austrian Academy of Sciences Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. Credit: Gabriele Colozza/IMBA Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids,...
How Should We Screen Transgender Patients for Cancer?
Vincent Richeux PARIS — Screening for breast, cervical, and prostate cancer should continue for transgender patients after they transition to their new identity, but the screening methods must be adapted. This was the main message of a presentation given by Gene De Haan, MD, obstetrician and gynecologist at the Kaiser Permanente Interstate Medical Office East...
Autism-associated gene appears to alter brain cell identity in the hippocampus
by UT Southwestern Medical Center This image, obtained from a mouse brain using a brightfield microscope, shows the richly diverse cells of the hippocampus pseudocolored with different hues. Maria Chahrour, Ph.D., and colleagues investigated how cells in the hippocampus are affected in autism spectrum disorder, showing that unique subtypes of excitatory and inhibitory neurons are particularly...
Stem Cell Research Paves Way Toward Regenerating Skeletal Muscle
UCLA researchers have made headway using muscle stem cells to regrow damaged muscle in mice. Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA are one step closer to developing stem cell therapies to regenerate skeletal muscle in humans. Working in mice, the UCLA team discovered how...
Treasure trove’ of new CRISPR systems holds promise for genome editing
An algorithm that can analyse hundreds of millions of genetic sequences has identified DNA-cutting genes and enzymes that are extremely rare in nature. Sara Reardon A computer generated molecular structure of the CRISPR–Cas9 protein using a guide RNA sequence to cut DNA. The CRISPR–Cas9 system (pictured) is used to find and cut specific DNA sequences.Credit:...
Dietary saturated fats may influence male hormone levels, new study suggests
By Pooja Toshniwal PahariaNov 23 2023 Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the European Journal of Clinical Nutrition, researchers investigated the relationship between dietary fatty acid consumption and serological steroid hormone-binding globulin (SHBG) and testosterone levels in middle-aged male residents of Eastern Finland. Study: Dietary fat quality and serum androgen concentrations in...