by Wiley Credit: Pixabay/CC0 Public DomainResearch in animals has shown that the diabetes drug dulaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist may reduce symptoms of depression. A new study published in Brain and Behavior reveals the mechanisms that are likely involved. By conducting a range of tests in mice treated with and without dulaglutide,...
by Dennis Thompson Statins have become the miracle medicine of modern heart care, lowering cholesterol levels and and guarding against heart attacks in millions of Americans. In fact, a running joke among doctors holds that statins are so helpful they should be put in the water supply. However, they aren’t right for all patients, and...
Peer-Reviewed Publication COLD SPRING HARBOR LABORATORY Spinal muscular atrophy, or SMA, is the leading genetic cause of infant death. Less than a decade ago, Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer showed this brutal disease can be treated by tweaking a process called RNA splicing. This breakthrough resulted in Spinraza, the first effective treatment...
NIH-funded study highlights importance of cholesterol screenings and educationPeer-Reviewed Publication NIH/NATIONAL HEART, LUNG AND BLOOD INSTITUTE More than 70% of American Indian young adults aged 20-39 and 50% of American Indian teens have cholesterol levels or elevated fat in the blood that put them at risk for cardiovascular disease, suggests a study supported by the...
by Regenstrief Institute Credit: Pixabay/CC0 Public DomainEvery year, millions of referrals are made by primary care physicians in the U.S. for patients needing consultations with specialists. The intention is for patients to be seen by specialists and then to return to their primary care providers, completing a process known as a referral loop. However, between a...
by Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra Replication stress induces lncRNAs associated to replicating chromatin. a (Top) Mechanism of action of hydroxyurea (HU) RNR: ribonucleotide reductase. (Bottom) Immunoblot analysis HCT116 cells treated with HU 1 mM for 8 h followed by 3 h recovery shows the reversible effect of HU on replication stress markers p-ATR,...
by Jeni Bushman, University of Illinois at Urbana-Champaign Summary of the effects from activation of mGluR7 on molecular and behavioral deficits in Fmr1 KO mice. Credit: EMBO Molecular Medicine (2024). DOI: 10.1038/s44321-024-00038-wFragile X syndrome is one of the most commonly inherited forms of autism and intellectual disability, and no treatment currently exists. But a team of...
by Julia Sarant, David Harris, Peter Busby, Jocelyn Phillips, Charlotte Anderson and Jack Hargreaves, University of Melbourne Comparative cognitive performance over 36 months for the HA and AIBL groups on the Cogstate Brief Battery. Scoring is based on speed and accuracy; therefore, increased scores indicate poorer performance. Relative to HA participants, scores for AIBL participants increased over...
by Melissa Moore, Rush University Medical Center Credit: Teona Swift from PexelsWe know that a colonoscopy is the most effective tool for the early detection and prevention of colon cancer. But anyone who has ever had a colonoscopy also knows that it’s not necessarily something to look forward to. “Many patients are hesitant to undergo this...
Which blood tests do you really need? And how often should you get them done? By Laura Entis detail of hand in blue nitrile glove holding vile of bloodPhoto: ShutterstockSometimes it may feel like almost every visit to the doctor includes a dreaded blood draw. Blood tests can reveal a lot about the state of...
