by Sarah McQuate, University of Washington Microscopy image of beta cells making IAPP (left) and IAPP plus one of the team’s synthetic peptides (right). Credit: Protein Science (2023). DOI: 10.1002/pro.4854Of the 38 million Americans who have diabetes, at least 90% have type 2, according to the Centers for Disease Control and Prevention. Type 2 diabetes occurs...
by Impact Journals LLC (A) Schematic representation of experimental design of senescence induction in the colon fibroblasts. Senescence was induced using hydrogen peroxide (H2O2, 400 μM), doxorubicin (doxo, 250 nM) or bleomycin (bleo, 10 ng/mL). Non-senescent proliferating (NS) cells were used as a control. (B) Representative SA- β -gal assay results at pH6 to confirm...
by Wellcome Trust Sanger Institute Credit: Unsplash/CC0 Public DomainThe microbiome can identify those who benefit from combination immunotherapy across multiple different cancers, including rare gynecological cancers, biliary tract cancers and melanoma. Researchers from the Wellcome Sanger Institute, the Olivia Newton-John Cancer Research Institute in Australia, and collaborators have identified specific strains of bacteria that are linked...
Nancy A. Melville A case of false-positive alcohol toxicology tests believed to be linked to treatment with sodium-glucose cotransporter 2 (SGLT2) inhibitors raises concern that the widely used diabetes drugs could feasibly be a cause of innumerable false-positive test results — with a lack of proper refrigeration of the samples being a key culprit. The...
by Duke University Medical Center Credit: Pixabay/CC0 Public DomainA perplexing problem for people with recurring urinary tract infections (UTIs) is persistent pain, even after antibiotics have successfully cleared the bacteria. Now Duke Health researchers have identified the likely cause—an overgrowth of nerve cells in the bladder. The finding, appearing March 1 in the journal Science Immunology,...
Andrew N. Wilner, MD; Ronald C. Petersen, MD, PhDDISCLOSURES Andrew N. Wilner, MD: Welcome to Medscape. I’m Dr Andrew Wilner. Today I have a special guest: Dr Ron Petersen. Dr Petersen is the lead author of a paper recently published in JAMA Neurology, entitled, “A New Framework for Dementia Nomenclature.” Welcome, Dr Petersen. Ronald C....
Researchers are reporting that some early-stage cancer cells activate a gene that helps hide them from the body’s immune response.They say that identifying this uptick in gene expression among cancer cells could lead to new pathways for early diagnosis and future treatment of colon cancer.Experts say more research is needed, however, to confirm these findings...
Caroline Apovian, MD Many patients with obesity blame weight gain on their metabolism. The reality is that metabolism can be blamed for weight regain after people try to lose weight! As we age, our metabolism does slow down; sometimes we think it stops working. Caroline Apovian, MD Metabolism, or resting energy expenditure, is directly related...
Rachel S. Rubin, MD Rachel S. Rubin, MD: I’m Dr Rachel Rubin, urologist and sexual medicine specialist in the Washington, DC, area. This is Sex Matters, and I’m here today with my friend and colleague, Dr Matt Ziegelmann, who is the sexual medicine expert at the Mayo Clinic and who does all things men’s health,...
Megan Brooks Replacing regular salt with a salt substitute reduced the incidence of new hypertension compared with a usual salt group, without provoking hypotension, new data showed. Among a group of older adults with normal blood pressure (BP), those who swapped table salt for a salt substitute — consisting of 62.5% sodium chloride, 25% potassium...
