by Elana Gotkine Children and adolescents with multiple sclerosis (MS) have a range of symptoms, signs, and diagnoses within five years before diagnosis, according to a study published online Dec. 27 in JAMA Network Open. Manas K. Akmatov, Ph.D., from the Central Research Institute of Ambulatory Health Care in Berlin, and colleagues systematically assessed diseases and...
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Stem cells ‘instructed’ to form specific tissues and organs
By Paul McClure December 26, 2024 Researchers have developed a way of guiding stem cells’ development Depositphotos View 1 Images Researchers have created a way to guide and control the development of stem cells into specific tissues and organs, opening the door to developing a means of one day tackling complex diseases like diabetes and Parkinson’s...
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Study reveals macrophages’ misunderstood role in lung fibrosis
by National Jewish Health Credit: Pixabay/CC0 Public Domain Researchers at National Jewish Health and colleagues have completed the first study comparing lung macrophages in multiple models of lung injury. The research indicates that macrophages previously described as “pro-fibrotic” are insufficient to cause fibrosis on their own, opening the door to research that can help advance the...
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Lupus Nephritis Biomarkers ‘Robustly’ Predict Clinical Response, Long-Term Kidney Damage
Tara Haelle December 09, 2024 132 Added to Email Alert WASHINGTON — An investigational 12-protein panel of urinary biomarkers predicted histologically active lupus nephritis (LN) with 86% accuracy, according to research presented at the American College of Rheumatology (ACR) 2024 Annual Meeting. The noninvasive biomarker panel “robustly predicts meaningful and actionable histological findings” in patients with...
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Plant-Based Diet Improves Uric Acid Levels, Gout Symptoms
Jim Kling November 25, 2024 2532 A Mediterranean-inspired plant-based diet improved self-reported measures of gout as well as uric acid levels, a pilot study has found. There hasn’t been a lot of research on diet in gout, according to Anna Kretova, RD, who presented the study at the annual research symposium of the Gout Hyperuricemia and...
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The Guide to Supplements for Rheumatologic Diseases
Julie Stewart November 04, 2024 5194 Added to Email Alert Many people with rheumatologic diseases try supplements for symptom relief. Here’s what you need to know about some common picks. Dietary supplements were a $159 billion business in the United States last year, and many people with rheumatologic diseases are buying in. Research suggests more than 6 in...
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Management of Children and Adolescents With Long COVID
Ute Eppinger December 23, 2024 570 Added to Email Alert Current management of children and adolescents with long COVID was the focus of various presentations at the 3rd Long COVID Congress in Berlin in November. The congress aimed to facilitate in-depth discussions on recent research projects, diagnostic procedures, and therapeutic approaches to enhance care for long COVID...
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Six Substudies From the Semaglutide Trials: Identifying Mechanisms of Benefit and Whom to Treat
Identifying Mechanisms of Benefit and Whom to Treat Neha J. Pagidipati, MD, MPHDisclosures J Am Coll Cardiol. 2024;84(17) 11 Added to Email Alerts Several trials have documented the cardiovascular (CV) benefits of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide, including the SELECT (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity), STEP-HFpEF (Effect...
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What you should know about pancreatic cancer screening
by Mayo Clinic Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domain Pancreatic cancer screening has advanced significantly in recent years. There are now research-based guidelines on screening for people at high risk of developing the disease, and researchers are collaborating to develop new screening approaches involving genetic testing and...
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FDA approves Tryngolza as adjunct to diet for familial chylomicronemia syndrome
by Elana Gotkine Tryngolza (olezarsen) has been approved by the U.S. Food and Drug Administration as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome (FCS), which can lead to potentially life-threatening acute pancreatitis (AP), according to a press release issued by Ionis Pharmaceuticals. Data have shown Tryngolza significantly and substantially...