Implantable device works like a tree branch to grab and fling proteinsPeer-Reviewed Publication Northwestern University image: The study’s first author, Hossein Zargartalebi, holds the tiny device. The implantable microdevice with the electrode and sensors inside a thin microneedle, the width of just three human hairs. Resembling a continuous glucose monitor, the device sits on the skin outside...
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Scientists discover new receptor for nerve growth factor—a promising target for treating pain
Cellular studies reveal neuropilin-1 is required for signaling pain and may offer a new approach for developing or repurposing therapies to address chronic painPeer-Reviewed Publication New York University image: Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice.view more Credit: Bunnett Lab Researchers at...
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Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
by University of Cambridge These images, from a small-scale unpublished study in human ovarian cancer patients, were created using a technique called hyperpolarized carbon-13 imaging that allows doctors to distinguish between different subtypes of ovarian cancer, to reveal their sensitivities to treatment. The scientists observed different rates of pyruvate conversion into lactate in different tumor deposits,...
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Adults grow new brain cells, and these neurons are key to learning by listening
by Aswathy Ammothumkandy, Charles Liu and Michael A. Bonaguidi, The Conversation Credit: Pixabay/CC0 Public Domain Your brain can still make new neurons when you’re an adult. But how does the rare birth of these new neurons contribute to cognitive function? Neurons are the cells that govern brain function, and you are born with most of the neurons...
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Five things young women need to know about menopause
by Megan Arnot, The Conversation Credit: Pixabay/CC0 Public Domain If you’re under 40, menopause might seem like the least of your worries right now. But for some women, this transition can happen earlier than they might expect—even as early as their 30s, in rare cases. And you almost certainly know a family member, friend or colleague who’s...
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Genetic risk for schizophrenia linked to a malformed skull
by St. Jude Children’s Research Hospital Research from the Zakharenko lab, St. Jude Department of Developmental Neurobiology published in Nature Communications revealed a gene deleted in 22q11.2 deletion syndrome results in malformed regions of the cerebellum, but the defect is a result of a local skull deformity. Pictured: first author on the paper Tae-Yeon Eom, PhD....
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How SARS-CoV-2 exploits human proteins to replicate
by Sara Lidman, Karolinska Institutet SARS-CoV-2 infection inhibited SGs formation independent of eIF2α. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-54996-3 Researchers at Karolinska Institutet have discovered how the SARS-CoV-2 virus, which causes COVID-19, manipulates human proteins to replicate and evade the immune system. The results have been published in Nature Communications. The new study shows that SARS-CoV-2 uses human proteins called G3BP...
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Research reveals possible link between protein G3BP1 and amyotrophic lateral sclerosis
by Free University of Brussels Liquid–liquid phase separation of G3BP1 is aggravated by R-rich C9orf72 DPRs. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2402847121 Researchers from the Structural Biology Brussels group at Vrije Universiteit Brussel (VUB) have uncovered a significant mechanism that may contribute to amyotrophic lateral sclerosis (ALS), a disease that causes muscle weakness...
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Study shows driving decision aid can help older adults with the difficult decision for when to stop driving
by Julia Milzer, CU Anschutz Medical Campus Credit: Pixabay/CC0 Public Domain Deciding when to stop driving can be challenging for older adults and their families. A study published today in the Journal of the American Geriatric Society shows that using a decision aid tool can be beneficial and help older adults when faced with this difficult decision. In a randomized clinical...
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Researchers develop new saliva test to rapidly identify paracetamol overdose
by University of Liverpool Credit: Pixabay/CC0 Public Domain A research team led by the University of Liverpool has developed an innovative new technique that can rapidly assess paracetamol levels from saliva. In a paper published in the journal BMC Medicine, the team demonstrate the clinical validity of a new mass spectrometry technology-based technique that can test a tiny drop...