by UT Southwestern Medical Center Mice with the citation (cit) allele of H2-Aa strongly inhibited melanoma growth. Credit: Journal of Experimental Medicine (2024). DOI: 10.1084/jem.20240797 UT Southwestern Medical Center researchers have identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the Journal of Experimental Medicine,...
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Traditional Hand Eczema Treatments May Face Obsolescence
Ted Bosworth December 18, 2024 8328 Added to Email Alert NEW YORK, NY — For immediate control of a hand eczema flare, the old soak and smear approach with moisturizers or corticosteroids might live on, but they are moving to the back of the shelf for chronic mild-to-moderate disease. Referring to the gamut of non-targeted...
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Detailed study reveals how cells coordinate to heal human wounds
by Anne Hammarskjöld, Karolinska Institutet Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.11.013 A new study from Karolinska Institutet maps the cellular and molecular dynamics of human wound healing in exceptional detail. The study was published in Cell Stem Cell. Self-healing of wounds is vital, but little is known about how cells cooperate during this process. To better understand this, researchers studied...
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New molecule-creation method a ‘powerful tool’ to accelerate drug synthesis and discovery
Posted Today A team of chemists from Scripps Research and Rice University has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study, published in Science, combines biocatalytic carbon-hydrogen oxidation and radical cross-coupling, offering a streamlined and cost-effective approach to creating complex, three-dimensional molecules. This innovation could help accelerate drug...
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Hidradenitis Suppurativa Linked to Inflammatory Eye Disease
Doug Brunk November 08, 2024 065 Added to Email Alert Nearly a quarter of patients with hidradenitis suppurativa (HS) experienced concomitant eye disease, and among those who did, nearly one third had a partial response with treatment, results from a systematic review showed.Hibo Rijal “Inflammatory and autoimmune comorbidities have been documented in HS, but the...
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Bijuva side effects: What you should know
Bijuva (estradiol/progesterone) is a brand-name capsule that’s prescribed for treating certain menopausal symptoms. As with other drugs, Bijuva can cause side effects, such as cardiovascular and vision problems. Bijuva has boxed warnings. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section later....
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ChatGPT search tool vulnerable to manipulation and deception, tests show
Exclusive: Guardian testing reveals AI-powered search tools can return false or malicious results if webpages contain hidden text Nick Evershed Tue 24 Dec 2024 03.00 EST Share The Guardian’s journalism is independent. We will earn a commission if you buy something through an affiliate link. Learn more. OpenAI’s ChatGPT search tool may be open to manipulation using hidden...
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Scientists Destroy 99% of Cancer Cells in Lab Using Vibrating Molecules
Health25 December 2024 ByDavid Nield Illustration of a cancer cell. (Science Photo Library/Canva Pro) Scientists have discovered a remarkable way to destroy cancer cells. A study published last year found stimulating aminocyanine molecules with near-infrared light caused them to vibrate in sync, enough to break apart the membranes of cancer cells. Aminocyanine molecules are already used in bioimaging as synthetic dyes....
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FDA Approves Second Generic Daily GLP-1 Drug for T2D
Miriam E. Tucker December 23, 2024 0564 The US Food and Drug Administration has approved a generic once-daily injectable version of the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide (Victoza, Novo Nordisk) to lower blood sugar in people aged 10 years or older with type 2 diabetes (T2D), as an adjunct to diet and exercise. The move follows...
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Allergic Contact Dermatitis: New Culprits
Stéphanie Lavaud December 19, 2024 023 New allergens responsible for contact dermatitis emerge regularly. During the Dermatology Days of Paris 2024 conference, Angèle Soria, MD, PhD, a dermatologist at Tenon Hospital in Paris, France, outlined four major categories driving this trend. Among them are (meth)acrylates found in nail cosmetics used in salons or do-it-yourself false nail kits...