This advance opens the door to new solutions for the treatment of conditions like obesity and other metabolic diseases linked to an excess of fatPeer-Reviewed PublicationCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)image: Adipocytes differentiated in vitro, containing fat deposits (yellow) and the Cav-1 protein in the cell membrane (magenta). Scale bar, 100 microns. b, Mouse adipose tissue. Scale...
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Novel CAR T cell therapy obe-cel demonstrates high response rates in adult patients with advanced B-cell ALL
by University of Texas M. D. Anderson Cancer Center Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAID Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell...
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Glioblastoma treatment shows promise in mouse study
by Justin Jackson , Medical Xpress GAD activity in immunocompromised setting. Credit: Nature (2024). DOI: 10.1038/s41586-024-08224-z Memorial Sloan Kettering Cancer Center-led researchers have identified a small molecule called gliocidin that kills glioblastoma cells without damaging healthy cells, potentially offering a new therapeutic avenue for this aggressive brain tumor. ADVERTISING Glioblastoma remains one of the most lethal primary...
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New Data: The Most Promising Treatments for Long COVID
Sara Novak November 27, 2024 25193 Long COVID is a symptom-driven disease, meaning that with no cure, physicians primarily treat the symptoms their patients are experiencing. Effective treatments for long COVID remain elusive because what works for one patient may be entirely ineffective for another. But as 2024 winds down, researchers have begun to pinpoint...
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Researchers propose a mathematical definition of cell death
by University of Tokyo An overview of the researchers’ ideas. Credit: 2024 Ivana Duic Urushibata. CC-BY-ND Cellular death is a fundamental concept in the biological sciences. Given its significance, its definition depends on the context in which it takes place, and lacks a general mathematical definition. Researchers from the University of Tokyo propose a new mathematical...
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A turning point for cancer treatment: Monocytes boost T-cells in immunotherapy
by Medical University of Vienna Computer-rendered image showing T cells (red) interacting with monocytes (yellow) and dendritic cells (blue) in the tumor microenvironment. These interactions help T cells to fully mature and effectively target and kill cancer cells. The scale bar (white) represents 10 micrometers (µm), indicating the size of the tumor regions shown. Credit: Obenauf...
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Autism and neural dynamic range: Insights into slower, more detailed processing
by Hebrew University of Jerusalem Credit: Unsplash/CC0 Public Domain A study appearing in Nature Neuroscience has linked distinct neural and behavioral characteristics in autism spectrum disorder (ASD) to a simple computational principle. Centered on the “dynamic range” of neurons, which reflects how gradually or sharply they respond to input, the study suggests that individuals with autism spectrum disorder have an increased dynamic...
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How small acts of kindness and connection really can change the world, according to psychology research
by Liza M. Hinchey, The Conversation Credit: Unsplash/CC0 Public Domain Political chasms, wars, oppression … it’s easy to feel hopeless and helpless watching these dark forces play out. Could any of us ever really make a meaningful difference in the face of so much devastation? Given the scale of the world’s problems, it might feel like...