by University of Tsukuba

Comparison of total phenolic compounds and antioxidant activity of CK, DA, and SH samples, and effect on 3T3-L1 cell viability. Credit: Scientific Reports (2025). DOI: 10.1038/s41598-025-85727-3

Obesity is a significant risk factor for various metabolic diseases and, in many cases, causes ectopic fat accumulation (i.e., the accumulation of fat around organs where it should not be), inflammation, and insulin resistance, resulting in the dysfunction of white adipose tissues (cells that store excess energy as fat) and excessive fat formation.

Several studies report that the pulp and shell of cashew nuts effectively reduce fat weight in human and animal models; however, the direct effects on adipocyte differentiation were not known. And although there has been a continuous increase in the global production and consumption of cashew nuts, their byproducts (pulp and shells) have not been effectively utilized.

Researchers at the University of Tsukuba discovered that extracts from cashew pseudofruit pulp (apple) and shell inhibit lipid accumulation and adipogenesis by downregulating the transcription factors involved in adipocyte differentiation.

In a study published in Scientific Reports, the researchers investigated the biological effects of the pulp and shells of cashew nuts on adipocyte differentiation by evaluating the gene expression and protein levels of adipogenic transcription factors and adipocyte markers.

The results show that the extract of cashew nut pulp reduces lipid accumulation in adipocytes and that of the nutshells significantly inhibits adipocyte differentiation. These findings suggest that the functional components of cashew nut byproducts are promising food and drug ingredients for preventing metabolic complications and maintaining good health.

More information: Munkhzul Ganbold et al, Inhibitory effects of cashew Anacardium occidentale L. kernel, apple, and shell extracts on lipid accumulation and adipogenesis in 3T3-L1 adipocytes, Scientific Reports (2025). DOI: 10.1038/s41598-025-85727-3

Journal information:Scientific Reports

Provided by University of Tsukuba

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