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New nasal vaccine shows promise in curbing whooping cough spread

by Tulane University aP-T-vant immunized mice eliminated B. pertussis from the lung and nasopharynx. Credit: npj Vaccines (2024). DOI: 10.1038/s41541-024-00990-1 As whooping cough cases rise in the U.S., a new nasal vaccine developed by Tulane University may hold the key to reducing the spread of the highly contagious respiratory disease. Current pertussis vaccines are widely used and effective...

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New COVID vaccine booster: Q&A on why you should wait

by Lisa M. Krieger, The Mercury News Credit: Unsplash/CC0 Public Domain Yes, older Americans should get yet another COVID shot—but if you have already gotten the latest version, there’s no rush. The Centers for Disease Control and Prevention last week said that people 65 and older or who are immunocompromised need a second dose of...

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Study finds common sleeping pill may reduce Alzheimer’s protein buildup, ScienceAlert reports

Study finds common sleeping pill may reduce Alzheimer’s protein buildup, ScienceAlert reports – © The Daily Galaxy –Great Discoveries Channel The relationship between sleep quality and Alzheimer’s disease has long intrigued researchers. Poor sleep patterns have been identified as an early warning sign of Alzheimer’s, often preceding more noticeable symptoms like memory loss and cognitive decline. Scientists...

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Study shows long-term, low-dose antiviral treatment benefits patients with eye disease and pain from shingles

Credit: Unsplash/CC0 Public Domain Long-term, low-dose antiviral treatment reduces the risk for potentially vision-damaging bouts of inflammation and infection, as well as pain, which occur when shingles affects the eye, according to new research presented October 19 at the annual meeting of the American Academy of Ophthalmology (AAO) in Chicago. Shingles occurs when the varicella-zoster virus, which...

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Study finds RSV vaccine highly effective in protecting older adults against severe disease, hospitalization and death

Credit: CC0 Public Domain A multi-state study, published in The Lancet, is one of the first real world data analyses of the effectiveness of the RSV—short for respiratory syncytial virus—vaccine. VISION Network researchers report that across the board these vaccines were highly effective in older adults, even those with immunocompromising conditions, during the 2023–24 respiratory disease season, the...

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mRNA vaccines for disease outbreaks can be synthesized in less time with new technique

The phosphorylation reagent with a nitrobenzyl hydrophobic tag allows production of high purity fully chemically synthesized mRNA and transcriptionally synthesized cyclic mRNA. Credit: Reiko Matsushita In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial. However, the speed of vaccine production...

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Mpox vaccine is safe and generates a robust antibody response in adolescents

NIH clinical trial addresses knowledge gap on vaccine use in adolescent populations Reports and Proceedings NIH/National Institute of Allergy and Infectious Diseases image:  Colorized transmission electron micrograph of mpox virus particles (light green) found within VERO E6 cells (teal). The virus particles are in various stages of maturity, which accounts for differences in shape. Captured...

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New strategy could turn intravenous medicines into pills

Examples of water-soluble prodrugs. a Orally administered therapeutics that possess a water-soluble promoiety (e.g. phosphate or phosphonooxymethyl group). b Intravenously administered commercial drugs possessing various water-soluble promoieties. Created in BioRender. Smith, M. (2024) BioRender.com/l22c048. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52793-6 For many people with cancer, intravenous (IV) infusions of chemotherapy are their best chance at a cure. But these infusions can...

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Newly discovered COVID vaccine targets may last longer

Workflow for the generation of SARS-CoV-2-derived HLA I and HLA II immunopeptidome data. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-51959-6 Melbourne researchers have discovered more than 200 new vaccine target candidates from the COVID-19 virus, SARS-CoV-2, that could lead to the development of vaccines with a longer lasting broader immunity than existing vaccinations. In a paper published in the journal Nature...

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Benzoyl peroxide acne drugs lack stability and degrade into carcinogenic benzene stored at room temp

Benzoyl peroxide (BPO) drug products, commonly used for extended periods of time to treat acne and rosacea, degrade into carcinogenic benzene when not refrigerated, a study published in the Journal of Investigative Dermatology reveals. Credit: Journal of Investigative Dermatology Investigators have determined that a substantial portion of topical benzoyl peroxide (BPO) acne and rosacea treatments currently on...