by Max Delbrück Center for Molecular Medicine Previously only suspected, now made it visible thanks to the molecular reporter: where human tumor cells and brain cells of a mouse meet, the tumor cells have a different identity than everywhere else (green). Credit: Gargiulo Lab, MDC Glioblastoma is the most common malignant brain tumor in adults. Roughly...
by La Jolla Institute for Immunology Enhancers serve as specific switches that turn on genes in a cell specific manner but it has been difficult to determine which switch is connected to which gene. Credit: Alex Fung The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies...
by UT Southwestern Medical Center Histopathology of gastrocnemius muscle from patient who died of pseudohypertrophic muscular dystrophy, Duchenne type. Cross section of muscle shows extensive replacement of muscle fibers by adipose cells. Credit: Public Domain A UT Southwestern research team has cataloged gene activity in the skeletal muscle of mice, comparing healthy animals to those carrying a genetic...
by University of Helsinki Credit: University of Helsinki Findings from the FinnGen study encompassing 120,000 women indicate that inherited breast cancer risk should be assessed in an increasingly comprehensive manner. Currently, only individual gene mutations are taken into consideration in breast cancer therapy and prevention. The study demonstrates that more extensive genomic data can be used...
by The Francis Crick Institute Images showing tumours developing in the stomach and spleen of mice in the presence of ALC1 but not in the mice without ALC1. Credit: The Francis Crick Institute Researchers at the Francis Crick Institute have found a new way to prevent some tumors from repairing their own DNA, a function that...
by Université libre de Bruxelles Credit: Unsplash/CC0 Public Domain Cancer metastasis, which is the dissemination of tumor cells into distant organs, is the leading cause of mortality in cancer patients. To undergo metastasis, cells must leave the primary tumor, circulate into the blood, colonize distant organs, and form distant metastasis. It has been proposed that epithelial...
by University of Illinois at Chicago A representative eye of a PAX6 deficient mouse after treatment (right) showing a better-developed eye and clear cornea compared to a control treated PAX6 deficient mouse eye (left) showing a smaller eye with scarring and blood vessel growth. Credit: University of Illinois Chicago Researchers at the University of Illinois Chicago have...
by Virginia Commonwealth University Credit: CC0 Public Domain Approximately 200,000 cancer patients are diagnosed with brain metastases each year, yet few treatment options exist because the mechanisms that allow cancer to spread to the brain remain unclear. However, a study recently published in the journal Cancer Cell by VCU Massey Cancer Center scientist Suyun Huang, M.D., Ph.D., offers...
by University of Virginia Credit: CC0 Public Domain Researchers at the University of Virginia have shed light on how our genes affect our risk for coronary artery disease, the most common form of heart disease. In addition to identifying gene variants that influence risk, they found that one gene in particular appears to have a protective effect....
by Weill Cornell Medical College Histone H1 (fragment shown here in gray) binds and condenses DNA to repress gene activity. Mutations in histone H1 (highlighted in red) have been identified at high frequency in many hematological malignancies. Credit: Weill Cornell Medical College Mutations in proteins called histone H1, which help package DNA in chromosomes, are a...
