by Ernie Mundell It was the ancient Greeks who first divided the 20-foot length of the small intestine into three parts: The duodenum, the jejunum and the ileum. However, the organ may finally be ready for an update: U.S. researchers say the small intestine is actually comprised of five distinct segments, each being responsible for...
by Germans Trias i Pujol Research Institute Pleiotropic RNYs are linked to SLE risk and plasma RNYs are relatively abundant preceding breast cancer diagnosis. a Scatter plot of the correlation of the levels of expression between RO60 and the pleiotropic or non-pleiotropic RNY signatures in TCGA normal tissue. The PCCs and p values are indicated....
by Case Western Reserve University Representative human spinal cord tissue imaged at 4X objective for DAPI (blue), CD80 (red), and Iba1 (green) from an C9ORF72 ALS case and a non-ALS control. Scale bars represent 1000 µm or 100 µm as indicated. Credit: Science Translational Medicine (2024). DOI: 10.1126/scitranslmed.adg7895Researchers at Case Western Reserve University School of Medicine...
by Max Delbrück Center for Molecular Medicine Mutated T cells are unable to kill B cells (red) induced by the Epstein-Barr virus. This causes other immune cells to flow into the area of infection, thereby blocking a blood vessel (center). Credit: Elijah D. Lowenstein and Xun Li, K. Rajewsky Lab, Max Delbrück CenterSome hereditary genetic defects...
by University of Auckland Credit: Pixabay/CC0 Public DomainA group of patients with a hereditary disorder have had their lives transformed by a single treatment of a breakthrough gene-editing therapy, according to the lead researcher of a trial published in the New England Journal of Medicine. The patients from New Zealand, the Netherlands and the UK have...
Gabriele Ciceri, Arianna Baggiolini, Hyein S. Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M. Walsh, Kelly A. Aromolaran, Alberto J. Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J. Sevilla, Peter A. Goldstein, Joshua Levitz, Christina S. Leslie, Richard P. Koche & Lorenz StuderNature (2024) AbstractThe pace of human brain development is highly protracted compared...
Peer-Reviewed Publication NYU LANGONE HEALTH / NYU GROSSMAN SCHOOL OF MEDICINE A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of...
by Keck School of Medicine of USC Credit: CC0 Public DomainAs people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19. In a new mouse study published in Science Advances, researchers from the USC Stem Cell lab of Rong Lu describe how...
First-ever RNA editing trial in US gets clearance, pitting ‘exon editing’ technology against vision lossRyan CrossSenior Science CorrespondentThe FDA told the Boston startup Ascidian Therapeutics that it can begin the first clinical tests of a therapy that “rewrites” RNA to correct roughly two-thirds of the genetic typos responsible for an inherited form of vision loss...
by University of Chicago DNA, which has a double-helix structure, can have many genetic mutations and variations. Credit: NIHA new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool, described in a new paper published January 26, 2024, in Nature Genetics, combines data...
