INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) ANALYSIS OF THE GENOMES OF 28,000 TUMORS FROM 66 TYPES OF CANCER. view more CREDIT: IRB BARCELONA Cancer is a group of diseases characterised by uncontrolled cell growth caused by mutations, and other alterations in the genome of cells. A tumour can present from hundreds to thousands of...
Interview conducted by Emily Henderson, B.Sc. Professor Guillermo Montoya spoke to News-Medical on his research that involved visualizing the largest and most complex CRISPR system, which could have potential applications in biomedical diagnostics. What provoked your research into CRISPR? My interest in protein-DNA interactions and genome editing started a while ago when I collaborated with...
Enhancement of motor function and muscle strength in aged mice by enhancing formation of neuromuscular junctions THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO THE THERAPEUTIC ADMINISTRATION OF AAV-D7, A VIRAL VECTOR CARRYING THE HUMAN DOK7 GENE, ENHANCES NMJ FORMATION AND INNERVATION TOGETHER WITH MOTOR FUNCTION AND MUSCLE STRENGTH IN AGED MICE (?2 YEARS…view...
by Sarah Lichtman, Cedars-Sinai Medical Center A study published today in the journal Nature could help explain why certain people who develop amyotrophic lateral sclerosis (ALS), a deadly neurological disorder also known as Lou Gehrig’s disease, are prone to autoimmune diseases. ALS, which has no known cure, causes progressive degeneration of nerve cells in the...
By Rich Haridy August 19, 2020 A new study is questioning whether potential Alzheimer’s treatments previously found to be ineffective in human trials should be re-examined, after the discovery of a specific gene that can inhibit a therapy’s efficacy is only present in 75 percent of people. The long-standing cholinergic hypothesis for Alzheimer’s disease suggests...
CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) DEVELOPMENT OF THE INITIAL STAGES OF PULMONARY FIBROSIS ASSOCIATED WITH AGEING IN NON-TREATED MICE (LEFT), THAT CAN BE PREVENTED IN MICE TREATED WITH THE TELOMERASE GENE THERAPY (RIGHT). view more CREDIT: CNIO Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that...
by Public Library of Science Most taste cells selectively respond to a specific stimulus type while broadly responsive cells respond to multiple taste qualities. Credit: Jhanna Flora and Kathryn Medler Our mouths may be home to a newly discovered set of multi-tasking taste cells that—unlike most known taste cells, which detect individual tastes—are capable of...
by Karolinska Institutet The disease multiple sclerosis (MS) attacks the central nervous system and, with time, can give rise to muscle tremors and loss of balance. Researchers at Karolinska Institutet have now identified a gene, Gsta4, that protects a certain kind of cell in the brain from being destroyed. It is hoped that the results...
Researchers report on a treatment approach that could normalize social behavior in autism UNIVERSITY OF BASEL A team of researchers at the Biozentrum, University of Basel, has discovered a new connection between a genetic alteration and social difficulties related to autism: A mutation in the neuroligin-3 gene reduces the effect of the hormone oxytocin. In...
by Institute for Research in Biomedicine – IRB Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer. The best known type of local hypermutation, called a mutation shower or thunderstorm, is quite uncommon and it leads to many mutations accumulated in...
