Scientists at Oak Ridge National Laboratory used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.ORNL scientists developed a method that improves the accuracy of the CRISPR Cas9 gene editing tool used...
Category: <span>Genetics</span>
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Novel menin inhibitors show promise for patients with advanced acute myeloid leukemias
by University of Texas M. D. Anderson Cancer Center Credit: CC0 Public Domain Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations. Results from the studies were shared...
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Researchers Redesign Future mRNA Therapeutics
Posted Today Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body.DNA – artistic interpretation. DNA – artistic interpretation. Image credit: Alius Noreika, created with Bing Image Creator In a collaboration of universities, including Dr Lance Turtle at the University of Liverpool, researchers have...
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How CRISPR gene editing could help treat Alzheimer’s
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations. Tosin Thompson A laboratory-grown cell that produces amyloid precursor protein. Such cells are cultured for use in Alzheimer’s research.Credit: Simon Fraser/Science Photo Library Last month saw the first-ever approval of a gene therapy that uses the CRISPR–Cas9 gene-editing tool, a...
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Genetically engineered cell therapies with mRNA lipid nanoparticles for transferrable platelets
by Thamarasee Jeewandara , Phys.org Platelets transfected with mRNA using LNP can express exogenous protein. (A) Schematic describing the transfection of platelets using mRNA-LNP. (B) NanoLuc expression, measured as the relative luminescence units (RLU) per total protein, using various transfection agents (n = 3). (C and D) Representative flow cytometry plots and quantification of median...
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One protein is key to the spread of lung cancer: New study finds a way to stop it
by Tulane University Credit: Pixabay/CC0 Public Domain A new study by Tulane University has uncovered a previously unknown molecular pathway that could be instrumental to halting lung cancer in its tracks. Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths in the world. The research, published in Proceedings of...
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Fighting leukemia with therapeutic RNA
by Goethe University Frankfurt am Main AML xenografts are susceptible to transient LNP/miR-193b treatment in vitro. A The absolute number of human AML PDX cells after treatment with single dose of 4 µg/ml LNPs. B Percentage of apoptotic cells (Annexin V+) on day 2 post treatment. A, B Data are represented as the mean ± standard deviation of three...
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Search algorithm reveals nearly 200 new kinds of CRISPR systems
By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.Allessandra DiCorato | Broad Institute Illustration of bacteria. Among ordered lines of bacteria, a single bacterium is highlighted in a circle, and a DNA strand can be seen withinCaption:Researchers...
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Decoding cell fate: Key mechanism in stem cell switch identified
by Institute of Molecular Biotechnology of the Austrian Academy of Sciences Top: Intestinal stem cells lacking Daam1 (left) or Rnf43 (right) form tumor-like organoids. Credit: Gabriele Colozza/IMBA Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids,...
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Treasure trove’ of new CRISPR systems holds promise for genome editing
An algorithm that can analyse hundreds of millions of genetic sequences has identified DNA-cutting genes and enzymes that are extremely rare in nature. Sara Reardon A computer generated molecular structure of the CRISPR–Cas9 protein using a guide RNA sequence to cut DNA. The CRISPR–Cas9 system (pictured) is used to find and cut specific DNA sequences.Credit:...