by Lori Solomon Individuals with psoriasis have double the odds of having celiac disease (CD) versus individuals without psoriasis, according to a research letter published online Feb. 9 in the Journal of the American Academy of Dermatology. Marina Z. Joel, from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined the association between psoriasis and...
by University of Oxford Credit: CC0 Public Domain A new study in The EMBO Journal has revealed how fat tissues might provide a protective role in intestinal inflammation opening new lines of research into the treatment of inflammatory bowel diseases. A fraction of inflammatory bowel disease (IBD) patients, predominantly those with Crohn’s disease, develop a phenomenon known...
by Friedrich–Alexander University Erlangen–Nurnberg Effects of CAR T cells on the manifestations of antisynthetase syndrome. (A) Neuropathology. Top, haematoxylin and eosin staining showing predominant perifascicular muscle atrophy and necrotic muscle fibers. Center left, staining for MHC-1 showing ubiquitous expression on muscle fibers with predominance at the perifascicular borders. Center right, connective tissue or perimysial fragmentation...
by Josh Barney, University of Virginia Separately housed Cd4creAhrfl/fl recover from EAE with increased myelin staining at chronic phase. (A) Clinical score of Cd4creAhrfl/fl and Ahrfl/fl mice cohoused (females; representative plot includes n = 9 mice/group; total replicates of N = 2 experiments). Spinal cords sections of Cd4creAhrfl/fl and Ahrfl/fl were stained with Luxol fast blue and hematoxylin/eosin stain at day...
by Kanazawa University Schematic diagram of induction mechanism of acute and chronic liver damage in severe fatty liver. Credit: Kanazawa University In hepatic steatosis, hepatocytes “die,” resulting in liver damage. Severe steatosis increases hepatocellular deaths, thus aggravating liver damage. The mechanism is unclear. Using mice, we show that mild steatosis causes apoptosis whereas severe steatosis...
Nancy A. Melville August 19, 2022 Vitamin D deficiency has a causative role in the systemic inflammation that commonly accompanies it, with inflammation declining, reflected by reductions in elevated C-reactive protein (CRP), as vitamin D levels increase to normal levels, new research shows. However, there is no reverse effect between the two: changes in CRP levels did not appear...
by Leiden University A transcriptome-wide analysis reveals genes associated with lipids. a Volcano plot depicting the relationship between linear regression effect size in the standard deviation of lipid levels and −log10(P-value) for the association between lipid levels and transcription for TG, HDL-C, and LDL. Points depicted in color represent genome-wide significant associations. The dashed horizontal...
AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Basic nutrition teaches that fat, when consumed in large quantities, is harmful to human health. However, the components that make up fats are complex. Good, unsaturated fats, or lipids, can lower disease risk. In fact, in a new study, researchers found that a good fat derivative may be able to...
by Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.) Electron microscopy images of lung macrophages in a normal mouse (left) and in a mouse deficient for mitochondrial oxidative phosphorylation (right). mn obtenida por microscopia electrónica de un macrófago pulmonar de un ratón normal (izquierda) y un macrófago con deficiencia en la fosforilación oxidativa mitocondrial (derecha)....
by Allessandra DiCorato, Broad Institute of MIT and Harvard Graphical abstract. Credit: Immunity (2023). DOI: 10.1016/j.immuni.2023.01.002 Researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital have constructed a high-resolution cellular map of Crohn’s disease, a chronic condition in which a hyperactive immune system causes inflammation throughout the gut, leading to symptoms including abdominal...
