by Medical College of Georgia at Augusta University Drs. Ruth and William Caldwell. Credit: Mike Holahan, Augusta University An enzyme under study to treat certain cancers is also showing promise in reducing the significant vision damage that can result from diabetes and premature birth, scientists report. Inflammation is considered a hallmark of cancer. It’s pervasive...
by Susanne Stöcker, Paul-Ehrlich-Institut – Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel Credit: Pixabay/CC0 Public Domain In the search for effective and safe therapeutics for hyposensitization, colleagues at the Paul-Ehrlich-Institut and the Justus Liebig University in Giessen investigated the effect of the birch pollen allergen-containing fusion protein rFlaA:Betv1 on B cells (specific immune cells). rFlaA:Betv1 leads...
by The Mount Sinai Hospital Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0 Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could...
by University of California, Los Angeles Credit: Pixabay/CC0 Public Domain Scientists are still trying to understand why many breast cancer survivors experience troubling cognitive problems for years after treatment. Inflammation is one possible culprit. A new long-term study of older breast cancer survivors published today in the Journal of Clinical Oncologyand co-led by UCLA researchers adds important...
by Garvan Institute of Medical Research Professor Mike Rogers. Credit: Garvan Institute of Medical Research A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease. The recessive disorder, called mevalonate kinase deficiency (MKD), is caused...
by Claudia Coons, UC Davis RNA-Seq variant calling identified a psoriasis-associated SNP in 3′ UTR of the PCSK9 gene. (A) SNP calling was performed on 2 separate psoriasis RNA-Seq data sets (12, 14), and ORs were calculated using the allele counting method. Fisher’s exact test was performed to calculate P values. Names of analyzed data sets...
by The Scripps Research Institute Scripps Research scientists have found a protein in immune cells (called neutrophils) that could be a target against harmful inflammation. An imaging technique called Stochastic Optical Reconstruction super-resolution Microscopy (STORM, right image) shows that in resting neutrophils, the WASH protein complex (green) forms a molecular clustered complex with microfilaments called...
by New York University A topical gel that blocks the receptor for a metabolic byproduct called succinate treats gum disease by suppressing inflammation and changing the makeup of bacteria in the mouth. Credit: Yuqi Guo A topical gel that blocks the receptor for a metabolic byproduct called succinate treats gum disease by suppressing inflammation and...
by UT Southwestern Medical Center Colonoscopic image of mice lacking the Pak2 gene showing severe colon inflammation. Credit: UT Southwestern Medical center A set of interacting molecules in immune cells of the gut is responsible for preventing the inflammation seen in inflammatory bowel diseases (IBD), UT Southwestern researchers report in a new study. The findings,...
by Harvard Medical School Inflammation is the body’s first line of defense, occurring as droves of immune cells rush to the site of injury or acute illness to make repairs and stem further damage. When successful, inflammation helps the body survive and heal after trauma. However, when the recovery following an inflammatory response goes awry, it signals...
