INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) IMAGE: DURING THE INFLAMMATORY PHASE, INFLAMMATORY MARKERS (IN GREEN) ARE LOCALIZED IN THE MACROPHAGES NUCLEUS (IN BLUE) TO ACTIVATE THE SYNTHESIS OF INFLAMMATORY ARNS. CREDIT: IRB BARCELONA Inflammation is a temporary reaction to infection or injury that is intended to attract cells of the immune system so they...
by Karolinska Institutet Graphical abstract. Credit: EMBO reports (2022). DOI: 10.15252/embr.202154499 The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet in Sweden have repurposed a cancer drug for treatment of neuroinflammatory diseases such as multiple sclerosis. A novel drug carrier was also developed...
KAROLINSKA INSTITUTET The nervous system is known to communicate with the immune system and regulate inflammation in the body. Researchers at Karolinska Institutet in Sweden now show how electrical activation of a specific nerve can promote healing in acute inflammation. The finding, which is published in the journal PNAS, opens new ways to accelerate resolution of...
By Nick Lavars May 16, 2022 A new discovery around excessive cell death in the body offers new hope of treating conditions driven by chronic inflammation Depositphotos Uncontrolled inflammation in the human body can drive a variety of serious health conditions, including cancer and rheumatoid arthritis, so discoveries around how it works can benefit the...
by University of Bonn Image of the junction between the danger sensor NLRP3 and its signal protein, shown in magnification with the calculated protein structure. Credit: Inga V. Hochheiser Redness, swelling and pain are signs of inflammation. It serves to protect the body from pathogens and foreign substances. Researchers from the Universities of Bonn and...
4 MAY 2022 10:45 AM BY GUNJAN SINHA In this artist’s concept, a dying neutrophil (purple) releases putative inflammation-resolving lipids such as lipoxin (yellow) as a macrophage (blue) starts to clear its remains.V. ALTOUNIAN/SCIENCE For 3 decades, biochemist Charles Serhan at Brigham and Women’s Hospital has been the torch bearer for “resolution immunology”—a research field...
by University of East Anglia Credit: Unsplash/CC0 Public Domain In the search for eternal youth, poo transplants may seem like an unlikely way to reverse the aging process. However, scientists at the Quadram Institute and the University of East Anglia have provided evidence, from research in mice, that transplanting fecal microbiota from young into old mice can reverse hallmarks of...
by University of Michigan A graphic depicting a person with lupus. Credit: Justine Ross, Michigan Medicine. People with lupus have overactive immune systems that attack their own tissue, causing inflammation throughout the body. Around 70-80% of them will develop skin disease as part of their condition. And while it’s thought that exposure to ultraviolet light triggers...
by Katherine Unger Baillie, University of Pennsylvania Inflammation in the gums can increase susceptibility to other forms of inflammation, such as arthritis, through changes to immune cell precursors in the bone marrow, according to new research led by Penn scientists and collaborators. Credit: Katie Vicari The immune system remembers. Often this memory, primed by past...
CORNELL UNIVERSITY ITHACA, N.Y. — A multi-year study of the role of E. coligut bacteria in Crohn’s disease finds that intestinal inflammation liberates chemicals that nourish the bacteria’s growth and promotes their ability to cause inflammation. The results identify new avenues for treatments that selectively disrupt the compounds that feed E. coli. The study, “Mucosal Metabolites...
