INSTITUT DU CERVEAU (PARIS BRAIN INSTITUTE) An unprecedentedly precise exploration of the molecular and electrophysiological basis of a form of autoimmune encephalitis, conducted by the “Cellular Excitability and Neuronal Network Dynamics” team at the Paris Brain Institute, elucidates for the first time a scenario for the onset of epileptic seizures in this pathology. The results, published...
Category: <span>Inflammation</span>
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A messenger substance considered to be inflammatory can alleviate asthma symptoms
by Friedrich–Alexander University Erlangen–Nurnberg Intranasal rIL-3 application during challenge induces Treg cells. (A) Experimental design for lung ILC2 skewing. (B) After 5 days of in vitro ILC2 differentiation, IL-10 release was measured in the supernatants of ILC2 skewed from the lung of wild-type (WT) asthmatic mice with and without additional rIL-3 treatment during sensitization or...
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Alpaca nanobodies target and dissolve root cause of chronic inflammation
By Nick Lavars April 19, 2022 Alpaca immune systems have some properties that may be very useful to medical science Depositphotos By tapping into the unique immune system of alpacas, scientists have developed a promising technique for tempering chronic inflammation associated with conditions such as arthritis. The breakthrough hinges on what are known as nanobodies,...
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Active resolution of inflammation: No evidence that specialized lipid messengers are involved
GOETHE UNIVERSITY FRANKFURT FRANKFURT. Inflammation is the result of an active defence reaction by our immune system. It mostly disappears by itself. It was once assumed to be a passive process because the immune cells involved, having done their work, gradually die off or migrate. Today, we know that our body also actively controls the...
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A new approach against chronic inflammation
by University of Bonn ASC specks shown here in different colors are large complexes of many copies of the ASC protein. They can cause immense damage in the tissue. Credit: Franklin Lab / University of Bonn The cells in our body have a sophisticated alarm system, the inflammasome. Its central component is the so-called ASC...
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E-cigarettes alter inflammatory state of brain, heart, lungs and colon, research shows
by University of California – San Diego Credit: Pixabay/CC0 Public Domain Researchers at University of California San Diego School of Medicine report that daily use of pod-based e-cigarettes alters the inflammatory state across multiple organ systems, including the brain, heart, lungs and colon. Effects also vary depending on the e-cigarette flavor, and can influence how...
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About 1 in 8 anaphylaxis cases thought to be caused by medications
by Medical Journal of Australia Credit: Pixelumina Photography on Unsplash Medications were implicated in 12% of Victorian public and private emergency department presentations with anaphylaxis, according to research published today by the Medical Journal of Australia. “From 1 November 2018, the Victorian Department of Health Department of Health and Human Services listed anaphylaxis as a notifiable...
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Inflammation caused by COVID-19, rather than the virus itself, may lead to loss of smell
by Johns Hopkins University School of Medicine Graphic showing how SARS-CoV-2 infection in the nasal passages leads to inflammation, which in turn, damages nerve cells and reduces the number of axons (impulse transmitters) available to send odor signals to the olfactory bulb (which helps the brain process them). This often results in weakening or complete...
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COVID-19: Inflammatory Insights
A study led by researchers at Harvard Medical School and Boston Children’s Hospital explains for the first time why COVID-19 causes severe inflammation in some people, leading to acute respiratory distress and multi-organ damage. Surprisingly, the study also finds that antibodies that people develop when they contract COVID-19 sometimes lead to more inflammation, while antibodies generated by...
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Newly identified neutrophil subset is a promising therapeutic target
UNIVERSITY OF ILLINOIS CHICAGO IMAGE: INTENSITIES OF PROTEIN EXPRESSION OF MARKERS ARE SHOWN ON VISNE MAP AS SPECTRUM COLORED DOTS, WITH LOW IN BLUE, HIGH IN RED. CREDIT: BACHMAIER, ET AL. ACS NANO Using a protein nanoparticle they designed, scientists at the University of Illinois Chicago have identified two distinct subtypes of neutrophils and found...