by European Alliance of Associations for Rheumatology, EULAR Credit: Unsplash/CC0 Public Domain EULAR, the European Alliance of Associations for Rheumatology, has developed new recommendations for CVR management in people with gout, vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD), Sjögren’s syndrome (SS), systemic lupus erythematosus (SLE), and antiphospholipid syndrome (APS). People with inflammatory...
by Walter and Eliza Hall Institute of Medical Research Graphical abstract. Credit: DOI: 10.1016/j.immuni.2022.01.003 A WEHI-led study has identified a molecular ‘culprit’ responsible for causing damaging levels of cell death and inflammation in the body. The findings could lead to improved treatment options for a range of conditions driven by inflammatory cell death, including the...
by Karolinska Institutet Fig. 1: Obesity is associated with altered phosphocreatine/creatine metabolism in human WAT. a, Polar metabolites in subcutaneous WAT of obese (n = 13) and non-obese (NO, n = 13) subjects (cohort 1) highlighting metabolites in the phosphocreatine/creatine pathway (green dots). Data are represented in a volcano plot with fold changes (log2) and adjusted P values (negative...
ELIFE Scientists have revealed that protracted inflammation following COVID-19 is strongly linked to long-term changes in lung structure and function, according to a report published today in eLife. The results suggest that monitoring people for markers of inflammation after infection with the SARS-CoV-2 virus could help identify those at risk of long-term lung problems and optimise...
by University of Bonn Looking at the CRID3 binding site in the NLRP3 protein. Credit: Johann F. Saba/UKB Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch. Their work shows which site of the giant protein called NLRP3 inhibitors can bind to. This opens the way...
by Technical University Munich Dr. Monica Yabal, research group leader at the Institute of Molecular Immunology (front), and her team have discovered how inflammatory bowel disease leads to a chain reaction that upsets the gut microbiome. Credit: Astrid Eckert / TUM Chronic inflammatory bowel disease (IBD) is becoming increasingly widespread. Until now, however, the underlying...
by New York University In normal tissue, PAR2—seen here in fluorescent green—is found on the surface of cells, but in inflamed tissue, it moves from the surface of cells to compartments within cells called endosomes. Credit: Bunnett Lab, NYU Dentistry Researchers at the NYU Pain Research Center have identified a mechanism that underlies inflammation and...
Chronic Obstructive Pulmonary Disease, or COPD, is the third leading cause of death worldwide. Yet despite its prevalence, the disease is not well understood on a cellular level. New Yale research has provided an unprecedented atlas of the cells in the COPD-afflicted lung, identifying those cells and pathways that may contribute to the reduced lung...
by Leslie Tate, Tulane University Identity of DRG cells responding to non-viable B. burgdorferi. DRG tissues were stained for immune mediators (green) and S100 (red). Positive staining for MCP-1 and IL-8 was seen in S100 positive cells, shown as yellow colocalizations (White arrows). Top panel is from Animal 3 tissue while the bottom panel is...
by Laval University Credit: Pixabay/CC0 Public Domain An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis. The team led by Éric Boilard of Université Laval has discovered that a protein naturally present in the gut acts on the microbiota and causes the formation of molecules that...
