by Ryan O’byrne, University of Alberta FIG 1 The massive elevation of plasma Gal-9 discriminates COVID-19 patients from healthy subjects. (A) Detected concentrations of Gal-9 in the plasma specimens of COVID-19-infected individuals compared to healthy controls (HCs) as measured by ELISA. (B) Detected plasma levels of Gal-9 in COVID-19 patients with mild/moderate or severe disease versus...
When a tissue experiences inflammation, its cells remember. Pinning proteins to their genetic material at the height of inflammation, the cells bookmark where they left off in their last tussle. Next exposure, inflammatory memory kicks in. The cells draw from prior experience to respond more efficiently, even to threats that they have not encountered before....
QUEEN MARY UNIVERSITY OF LONDON In a new study, published recently in the journal Circulation Research, scientists discover how the production of protective molecules known as specialized pro-resolving mediators (SPM) is altered in patients with COVID-19. The results suggest that treatments that increase SPM production, such as dexamethasone or SPM based drugs, could play a...
by Tokyo Medical and Dental University The small intestine is composed of duodenum, jejunum, and ileum (left). IgA deficiency causes distortion of the gut microbiota, especially in the ileum, and inflammatory cytokines are secreted from T cells, resulting in inflammation of the ileum (right). Credit: Tokyo Medical and Dental University While researchers have known for years that...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Researchers at Michigan Medicine have discovered yet another functional autoantibody in COVID-19 patients that contributes to the disease’s development and the “firestorm” of blood clots and inflammation it induces. A growing body of studies suggests COVID-19 emulates many aspects of systemic autoimmune disorders, including the release of a flurry of...
Today’s open access commentary is a good companion piece to a recent paper covering the use of mesenchymal stem cell therapies to suppress age-related chronic inflammation. These first-generation stem cell therapies have proven to be unreliable when it comes to the original goal of regeneration of organ function, but they do reliably reduce excessive inflammation for some months. Transplanted stem...
by Kumamoto University Ar-turmerone has an asymmetric carbon that naturally exists in a structure similar to A (S-Tur). Researchers identified three analogs (B, C, and D) that have stronger anti-inflammatory activity than S-Tur. Credit: Hori, Y. et.al., Cells, 2021, CC by 4.0 Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic...
by Brigham and Women’s Hospital Micrograph showing inflammation of the large bowel in a case of inflammatory bowel disease. Colonic biopsy. Credit: Wikipedia/CC BY-SA 3.0 The world of microbes living in the human gut can have far-reaching effects on human health. Multiple diseases, including inflammatory bowel disease (IBD), are tied to the balance of these microbes,...
Researchers at Case Western Reserve University have discovered a new technique to control inflammatory disorders that also maintains a patient’s ability to fight off infections. Principal investigator Carlos Subauste, professor of medicine and pathology at the Case Western Reserve School of Medicine, and his team have identified the interaction of particular proteins as a therapeutic target...
by EULAR Figure 1 Example outlining the different steps of the analysis from a meaning unit to lower and higher-level concepts. PROMs, patient-reported outcome measures. Inflammatory arthritis is the name of a group of diseases that cause joint pain and swelling. This happens because the body’s immune system attacks its own tissues and causes inflammation....
