by Delthia Ricks , Medical Xpress Credit: Pixabay/CC0 Public Domain One of the many wonders—and mysteries—of human biology is the complex response of the innate immune system, which is known for its swiftness in annihilating invading pathogens and capacity to mount an explosive inflammatory response. The body’s ability to rapidly sense and react to infiltrating...
by UT Southwestern Medical Center A UTSW study identified a type of blood vessel cell that triggers inflammation in fat tissue. Above, inflammatory immune cells (green) surround fat cells (red) in obesity and contribute to the development of metabolic disease. Credit: UT Southwestern Medical Center Dec. 30, 2020—When fat cells in the body are stuffed with...
by UT Southwestern Medical Center Sherwood Brown, M.D., Ph.D. Credit: UT Southwestern Medical Center Recently published UT Southwestern research reveals new insights about risk factors for depression based on data from a landmark longitudinal study focused on heart disease. One study, published in the Journal of Clinical Psychiatry, shows a link between an inflammatory molecule in the...
by Johannes Angerer, Medical University of Vienna Credit: CC0 Public Domain Every year, liver cirrhosis is responsible for approximately 170,000 deaths in Europe and recent epidemiological data show Austria to be in second place in regard to prevalence of cirrhosis in Europe. Excessive alcohol consumption, poor dietary habits, and metabolic comorbidities are the most common causes...
by Association RUVID Credit: CC0 Public Domain A study directed by Isabel Fariñas and published in the journal Cell Stem Cell reveals that the inflammation produced by a bacterial infection alerts brain stem cells and prepares their activation for the production of new neurons. The study represents a new advance in the field of regenerative medicine. Tissues are...
by WEHI Hallmarks of inflammation. An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19. WEHI’s Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was...
by St. Jude Children’s Research Hospital (L-R) Bhesh Sharma, Ph.D., Thirumala-Devi Kanneganti, Ph.D., Rajendra Karki Ph.D., of the Kanneganti Lab at St. Jude Children’s Research Hospital The COVID-19 pandemic continues to cause significant illness and death while treatment options remain limited. St. Jude Children’s Research Hospital scientists have discovered a potential strategy to prevent life-threatening inflammation, lung damage and organ...
by Cincinnati Children’s Hospital Medical Center These histology images show that mice with dysfunctional BCAP protein were not able to repair their intestinal crypts during the recovery from infection. Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new study led by experts...
Researchers from the National Institutes of Health (NIH) have discovered a new inflammatory disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome (VEXAS), which is caused by mutations in the UBA1 gene. VEXAS causes symptoms that included blood clots in veins, recurrent fevers, pulmonary abnormalities and vacuoles (unusual cavity-like structures) in myeloid cells. The scientists reported their...
Both eczema and psoriasis are inflammatory skin diseases that affect many individuals. Now, researchers from Karolinska Institutet and KTH in Sweden have made progress in mapping new candidate genes for these hereditary skin diseases. This may in the long run open up new ways of treating the diseases. The findings are published in the Journal of Allergy...
