Rutgers researchers discovered a new role the protein may have in helping to treat allergies, asthma, COPD RUTGERS UNIVERSITY A Rutgers-led team may have found the key to treating inflammatory diseases like asthma, allergies, chronic fibrosis and chronic obstructive pulmonary disease (COPD). In a study published in the journal Nature Immunology, researchers discovered that neuromedin...
Category: <span>Inflammation</span>
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Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy (Boston)– Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation,...
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The yin and yang of inflammation controlled by a single molecule
Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system’s inflammation response to infection. By using both specially cultured cells and small animal models, HDAC3 was found to be directly involved in the production of agents...
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AsEH enzyme: A new pharmacological target against Alzheimer’s disease
Drugs with neuroprotector effects UNIVERSITY OF BARCELONA FROM LEFT TO RIGHT, SANTIAGO VÁZQUEZ, CARLES GALDEANO, MERCÈ PALLÀS AND CHRISTIAN GRIÑÁN-FERRÉ (FACULTY OF PHARMACY AND FOOD SCIENCES/UNIVERSITY OF BARCELONA)…. view more CREDIT: UNIVERSITY OF BARCELONA A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer’s disease. The results show the...
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Spatial mapping method pinpoints potential new therapeutic targets in lupus
by Children’s Hospital of Philadelphia A team of researchers from Children’s Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders. The findings were published...
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Location, location, location: Even gut immune response is site-specific
by Julius-Maximilians-Universität Würzburg The pictures show the same stomach organoids: It shows the cell nuclei (blue) and the skeleton of the cell (pink) as a cross-section of the organoids. In grey is the microscopic picture of the organoids. A single organoid here is about a quarter millimeter in size. Credit: Julius-Maximilians-Universität Würzburg, JMU Why is...
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“Targeting peptide” discovery offers hope as new, highly effective anti-inflammatory
Designer peptide could become effective in reducing damage caused by COVID-19 infections UNIVERSITY OF TORONTO – FACULTY OF DENTISTRY TORONTO, ON (June 30, 2020) — A collaboration between the University of Toronto’s Faculty of Dentistry and the National Jewish Health in Denver — the top-ranked respiratory research hospital in the U.S. — has yielded a...
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In mouse study, black raspberries show promise for reducing skin inflammation
by Laura Arenschield, The Ohio State University Eating black raspberries might reduce inflammation associated with skin allergies, a new study indicates. In a study done with mice and published earlier this month in the journal Nutrients, researchers found that a diet high in black raspberries reduced inflammation from contact hypersensitivity—a condition that causes redness and...
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Fat check: Yale researchers find explanation for stress’ damage in brown fat
In their search for what triggers the damaging side-effects caused by acute psychological stress, Yale researchers found an answer by doing a fat check. In the face of psychological stress, an immune system response that can significantly worsen inflammatory responses originates in brown fat cells, the Yale team reports June 30 in the journal Cell....
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Researchers find on-off switch for inflammation related to overeating
by Brita Belli, Yale University Researchers at Yale have identified a molecule that plays a key role in the body’s inflammatory response to overeating, which can lead to obesity, diabetes, and other metabolic diseases. The finding suggests that the molecule could be a promising therapeutic target to control this inflammation and keep metabolic diseases in...