by Sara Bock, University of California Comparison of HylA and HylB with bacterial and animal Hyl. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-43833-8In a groundbreaking development in the field of anti-acne therapies, a team of researchers at University of California San Diego School of Medicine has created an acne vaccine that successfully reduces inflammation in a...
by The Mount Sinai Hospital Mice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls. Credit: Kim et al., Cell. Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or...
by Koen Stein, Vrije Universiteit Brussel Panx1-targeting nanobodies interact with the NLRP3 inflammatory cascade in acetaminophen-overdosed mice. a Overview of the NLRP3 signaling cascade in acetaminophen (APAP)-induced hepatotoxicity. Overdosing mice with APAP triggers oxidative metabolization catalyzed by cytochrome (CYP) P450 enzymes in hepatocytes. Associated-NAPQI formation causes necrosis, which triggers a Panx1-mediated inflammatory response in the...
by University of Bonn Immunofluorescence – staining of MAIT cells (green) next to mononuclear phagocytes (red) in kidney sections of mice with experimental glomerulonephritis. Cell nuclei in blue. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-43269-0Researchers from the University Medical Center Hamburg-Eppendorf and the University Hospital Bonn have demonstrated that certain derivatives of vitamin B2 can alleviate...
by Radiological Society of North America Infographic—New Treatment Restores Sense of Smell in Patients with Long COVID. Credit: RSNA Using an image-guided minimally invasive procedure, researchers may be able to restore the sense of smell in patients who have suffered with long-COVID, according to research being presented next week at the annual meeting of the Radiological...
by American College of Physicians Credit: CC0 Public Domain A randomized controlled trial that included more than 300 people diagnosed with chronic spontaneous urticaria (CSU)—hives—has found that acupuncture may offer limited relief from the condition, but clinical significance of this finding was unclear. The study is published in Annals of Internal Medicine. CSU is the most...
by Nemours Children’s Health System Credit: CC0 Public Domain Laser epilation, commonly known as laser hair removal, reduced the risk of recurrence in patients with pilonidal disease, an inflammatory, painful, and sometimes chronic or recurring condition, according to research conducted by Peter C. Minneci, M.D., Chair of Surgery at Nemours Children’s Health, Delaware Valley, and published...
by Impact Journals LLC Microscopic image of the expression of the cytoplasmic immunohistochemical reaction to IL-6. Credit: Aging (2023). DOI: 10.18632/aging.205091 A new research paper titled “Tissue immunoexpression of IL-6 and IL-18 in aging men with BPH and MetS and their relationship with lipid parameters and gut microbiota-derived short chain fatty acids” has been published...
by University of Cambridge Graphical abstract. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI162129 A cancer drug currently in the final stages of clinical trials could offer hope for the treatment of a wide range of inflammatory diseases, including gout, heart failure, cardiomyopathy, and atrial fibrillation, say scientists at the University of Cambridge. In a study,...
by Elana Gotkine For patients with moderate-to-severe prurigo nodularis, nemolizumab improves symptoms, according to a study published in the Oct. 26 issue of the New England Journal of Medicine.Shawn G. Kwatra, M.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues conducted a phase 3, double-blind, randomized trial involving adults with moderate-to-severe...
