by European Alliance of Associations for Rheumatology, EULAR Credit: Unsplash/CC0 Public Domain Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement. Systemic sclerosis (SSc) or scleroderma is another rheumatic autoimmune disease that affects blood vessels, skin, and visceral organs. EULAR has previously published recommendations for the management of these two conditions...
by Bob Yirka, Medical Xpress Example features and the species encoding the enzymes and pathways involved in the differential encoding of vitamin B processing in inflammatory arthritis. (A) Shown are examples of the most differentially encoded B vitamin pathways and enzymes. (B) Shown are the taxa contributing to vitamin B7 encoding. Credit: Science Translational Medicine (2023). DOI:...
by Kendall Daniels, University of North Carolina at Chapel Hill School of Medicine Histologic image of hidradenitis suppurativa. Credit: University of North Carolina at Chapel Hill School of Medicine University of North Carolina at Chapel Hill (UNC) School of Medicine researchers Christopher Sayed, MD, Yun Li, Ph.D., and Karen Mohlke, Ph.D., discovered the genomic locations that contribute to...
by Nadine A Yehya, University of California 3D renderings of L5 lumbar spine segments showing SARS-CoV-2 induced systemic bone loss in both male and female mice. Credit: University of California A UC Davis Health study that looked at acute bone loss in mice who had COVID-19 showed that SARS‐CoV‐2 infection can cause significant changes in...
by Josh Barney, University of Virginia Age-related changes in whole-blood gene expression are associated with increased inflammatory gene transcription and decreased expression of genes encoding mitochondrial Ca2+ transport. Credit: Nature Aging (2023). DOI: 10.1038/s43587-023-00436-8 University of Virginia School of Medicine researchers have discovered a key driver of chronic inflammation that accelerates aging, a finding that could lead to longer, healthier...
by Association of Basic Medical Sciences of FBIH Molecular mechanism of miR-212-3p in AD-induced neuroinflammation. Credit: Bosnian Journal of Basic Medical Sciences Alzheimer’s disease (AD) is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells to die. AD is the most common cause of dementia—a continuous decline in thinking, behavioral, and...
by Agency for Science, Technology and Research (A*STAR), Singapore A 12-month longitudinal systemic cytokine analysis of COVID-19 patients reveals a cluster of patients with persisting elevations of proinflammatory cytokines. Longitudinal plasma samples were collected across 5 time points up to 12 months post-illness onset from 78 COVID-19 patients. Concentrations of 45 immune mediators were quantified using a 45-plex...
MEDICAL UNIVERSITY OF VIENNA Osteoarthritis was long considered to be the result of wear and tear in advanced age. In the meantime, more and more studies are linking the degradation of articular cartilage to inflammatory and metabolic processes in the joint. In researching these processes, a scientific team led by MedUni Vienna has made significant...
By George Spencer UCSF Magazine Summer 2023 UCSF infectious disease specialist Michael Peluso, MD, who co-leads one of the world’s oldest studies of long COVID, discusses the condition’s mysteries. “There is no smoking gun,” he says. “If that were the case, we would have figured this out two years ago.” Michael Peluso, MD, Assistant Professor of Medicine What...
YORK UNIVERSITY TORONTO, CANADA, June 15, 2023 – Researchers have long known that moderate exercise has a beneficial impact on the body’s response to inflammation, but what’s been less understood is why. New research coming out of York University done on a mouse model suggests that the answers may lie at the production level of macrophages — white blood cells responsible for killing off...
