by La Jolla Institute for Immunology Credit: Pixabay/CC0 Public Domain Asthma is more dangerous than many people realize. An estimated 10 Americans die everyday from asthma, and the disease leads to around 439,000 hospitalizations and 1.3 million emergency room trips each year. “Asthma is one of the most important allergic diseases to study,” says Professor Toshiaki...
Researchers examined the disease while going beyond current diagnostic tools. Psoriatic disease severity is identifiable through cellular activity and signaling pathways, according to new research. In a new study1 published in Science Immunology, investigators at the New York University Grossman School of Medicine sought to map inflammatory features of psoriasis through a comparison of patients with varying...
OHIO STATE UNIVERSITY COLUMBUS, Ohio – Therapeutic nanocarriers engineered from adult skin cells can curb inflammation and tissue injury in damaged mouse lungs, new research shows, hinting at the promise of a treatment for lungs severely injured by infection or trauma. Researchers conducted experiments in cell cultures and mice to demonstrate the therapeutic potential of these nanoparticles, which...
by NYU Langone Health Spatial transcriptomics faithfully maps gene expression in healthy human skin. Credit: Rochelle L. Castillo, Ikjot Sidhu, Jose U. Scher, and Shruti Naik Beneath and beyond the reddish, flaky lesions that form in the skin of those with psoriasis, mild and severe forms of the disease can be told apart by the activity...
by St. Jude Children’s Research Hospital Graphical Abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.05.005 Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme. Free heme can cause significant inflammation and organ damage, leading to morbidity and mortality. Researchers from St. Jude Children’s Research Hospital discovered NLRP12, an innate immune pattern recognition receptor,...
by Weizmann Institute of Science Twelve days after injury, the lining of the colon was much more inflamed in mice lacking the NLRP10 inflammasome in their intestinal epithelial cells (bottom) than in the controls (top). Credit: Weizmann Institute of Science A new study by Prof. Eran Elinav’s lab at the Weizmann Institute of Science got an...
Ankylosing spondylitis (AS) is an inflammatory arthritis that typically causes inflammation or swelling in the spine’s ligaments and joints. It can cause pain and stiffness, which may worsen over time, leading to vertebrae fusion. The inflammation associated with AS can be widespread, which means a person can experience symptoms in other areas of the body....
CLEVELAND CLINIC CLEVELAND – Inhibiting a protein on the surface of immune cells could offer new strategies for treating severe asthma, Cleveland Clinic researchers found. Researchers discovered a new way a protein called MCEMP1 contributes to severe inflammation in the airway and lungs. The discovery, published in Nature Communications, provides critical information for developing therapeutic interventions to treat long-term...
by Medical College of Georgia at Augusta University Sadanand Fulzele, DVM, PhD, and first author and postdoctoral fellow Sagar Vyavahare, PhD. Credit: Michael Holahan, Augusta University Inhibiting a tiny RNA whose levels significantly increase with age, along with problems like weaker bones and sagging muscles, may be a way to keep our bodies more youthful and...
by Jeff Hansen, University of Alabama at Birmingham Knowledge of this previously unrecognized mechanism may aid therapy for patients with interleukin-6 signaling mutations and hyper-IgE Syndrome, or HIES. Credit: University of Alabama at Birmingham The immune system has a biological telecommunications system—small proteins known as interleukins that send signals among the leukocyte white blood cells to...
