MAY 2ND, 2023 CONN HASTINGS MEDICINE Researchers at the Harvard Wyss Institute have developed a new type of cell therapy for multiple sclerosis patients. The technique involves taking a blood sample from the patient being treated, isolating a sample of myeloid white blood cells, and then modifying them with ‘backpacks’ that contain anti-inflammatory molecules. The modified cells...
by Niigata University Credit: Pixabay/CC0 Public Domain Researchers from Niigata University and Kyoto Prefectural University have revealed that small vesicles, around 100 nm in size, released by intestinal bacteria induce immune activation and progression of liver cirrhosis, as well as a reduction of serum albumin levels, subsequently leading to edema and ascites. The research is published in the...
by Rockefeller University Blood vessels in the soft tissue between joints, during a rheumatoid arthritis flare-up. Credit: Laboratory of Molecular Neuro-oncology at The Rockefeller University It’s a well-documented medical mystery: Patients with gum disease are less likely to respond to rheumatoid arthritis treatments. But new research may help explain this link between gum disease and an otherwise disparate...
By RCSI University of Medicine and Health Sciences A new international study led by RCSI University of Medicine and Health Sciences has revealed significant potential for digital technology to improve asthma control for patients. The study, published in The Lancet Respiratory Medicine, examined the effectiveness of combining information from digital device in a digital platform to effectively manage uncontrolled...
Reviewed by Emily Henderson, B.Sc. Mar 28 2023 Scientists have identified an autoinflammatory disease caused by mutations in the LYN gene, an important regulator of immune responses in health and disease. Named Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI), the identification sheds light on how genes linked to certain illnesses can potentially be targets for treatment by repurposing...
by Nagoya University Enzyme-regulating macrophages found in both humans and mice open the door to translating findings in mice into human therapies. Credit: Issey Takahashi Researchers at Nagoya University in Japan have identified two enzymes that are involved in macrophage polarization, one of the key factors affecting fibrosis. The group’s findings, reported in Cell Death &...
by University of Bonn If the mitochondria (light blue) are damaged, the NLRP10 “smoke detector” sounds the alarm and forms with other proteins into an inflammasome (red). Ultimately, this leads to the demise of the cell and its disposal. Credit: Kim S. Robinson/Skin Research Institute Singapore Researchers at the Universities of Bonn and Singapore have discovered a new...
by Tohoku University Images of skin lesions can vary significantly depending on the distance between the lesion and the imaging device. By minimizing the imaging bias caused by distance, the accuracy of skin lesion differentiation can be enhanced. Credit: Yuta Yanagisawa et al Atopic dermatitis skin lesions and the lesions produced by infectious complications of...
Immune cells that keep the brain free of debris but also contribute to inflammation are the likely culprits behind the concentration and memory problems that sometimes follow one type of chemotherapy, a new study in mice suggests. Researchers previously showed that female mice given paclitaxel, a drug commonly used to treat breast, ovarian and other cancers, developed memory problems...
TRINITY COLLEGE DUBLIN Scientists working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and – in doing so – unearthed a potential new therapeutic target. The scientists...
