by Medical College of Georgia at Augusta University Dr. Alexis Stranahan. Credit: Michael Holahan, Augusta University Females’ propensity to deposit more fat in places like their hips, buttocks and the backs of their arms, so-called subcutaneous fat, is protective against brain inflammation, which can result in problems like dementia and stroke, at least until menopause,...
by Rebecca Brierley, University at Buffalo Graphical abstract. Credit: Molecular & Cellular Proteomics (2022). DOI: 10.1016/j.mcpro.2022.100409 Researchers from the University at Buffalo School of Pharmacy and Pharmaceutical Sciences recently published in Molecular & Cellular Proteomics, describing their work in identifying key metabolic regulators involved in cancer cell resistance to gemcitabine (Gem), a standard-of-care chemotherapy for pancreatic dual adenocarcinoma...
by Karolinska Institutet Schematic illustration of mechanisms underlying SARS-CoV-2-induced adipose atrophy and weight loss. SARS-CoV-2 infection triggers dyspnea and pathological changes in the infected lung tissues, including pulmonary edema, inflammation, and obstruction of pulmonary alveoli. These pathological alterations induce local hypoxia in the lung tissue and systemic hypoxia in other tissues. Hypoxia serves as a...
by Chinese Academy of Sciences Refeeding after various types of dietary restriction induces quick fat mass accumulation. a, Experimental design of SDR in mice feeding with 1-d food in 3 d or 4-d food in 6 d. AL, ad libitum; SDR(33.3% × 3), 33.3% food daily provided from day 1 to 3; SDR(66.7% × 6), 66.7% food daily provided from day 1...
Researchers have long been working on how to treat obesity, a serious condition that can lead to hypertension, diabetes, chronic inflammation, and cardiovascular diseases. Studies have also revealed a strong correlation between obesity and cancer–recent data show that smoking, drinking alcohol, and obesity are the biggest contributors to cancer worldwide. The development of fat cells, which...
COLUMBIA UNIVERSITY SCHOOL OF ENGINEERING AND APPLIED SCIENCE IMAGE: ILLUSTRATION OF DEPOT-SPECIFIC TARGETING OF FAT BY CATIONIC NANOMATERIALS CREDIT: NICOLETTA BAROLINI/COLUMBIA UNIVERSITY New York, NY—December 1, 2022—Researchers have long been working on how to treat obesity, a serious condition that can lead to hypertension, diabetes, chronic inflammation, and cardiovascular diseases. Studies have also revealed a...
by Technical University Munich SAT and VAT are characterized by different transcriptomic signatures. (a) MDS plot displaying the first two dimensions of the data (n = 99). (b) Hierarchical clustering of SAT and VAT samples based on euclidean sample distances (n = 99). (c) Volcano plot showing differentially expressed genes between SAT and VAT (n = 99). (d) Dotplot displaying the...
by University of Nottingham Credit: CC0 Public Domain Researchers have discovered the vital role of a hormone, which develops in men during puberty, in providing an early prediction of whether they could develop certain diseases in later life. Scientists from the University of Nottingham have discovered that the novel insulin-like peptide hormone, called INSL3, is...
by Wolters Kluwer Health Graphical abstract. Credit: Journal of Urology (2022). DOI: 10.1097/JU.0000000000002928 The standard cutoff point for low testosterone levels may not be accurate for men in their mid-forties and younger, reports a study in the Journal of Urology. “Young men have different testosterone reference ranges than older men,” comments lead author Alex Zhu, DO, of University...
HOKKAIDO UNIVERSITY IMAGE: FROM LEFT: SHINGO TAKADA, HOKKAIDO UNIVERSITY AND HOKUSHO UNIVERSITY; SHINTARO KINUGAWA, KYUSHU UNIVERSITY; AND HISATAKA SABE, HOKKAIDO UNIVERSITY (PHOTOS: SHINGO TAKADA, SHINTARO KINUGAWA, HISATAKA SABE). CREDIT: SHINGO TAKADA, SHINTARO KINUGAWA, HISATAKA SABE Investigations in Japan have uncovered some molecular mechanisms behind mitochondrial dysfunction in chronic heart failure. Chronic heart failure causes the...
