by American Society for Bone and Mineral Research Credit: Pixabay/CC0 Public Domain The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found. When cancer patients develop cachexia, their...
ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY IMAGE: DR. RAHUL AGGARWAL IS THE LEAD INVESTIGATOR FOR PRESTO (AFT-19) AND CO-LEADER FOR THE GU MEDICAL ONCOLOGY PROGRAM AT THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO. CREDIT: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Boston, MA (September 9, 2022) – The Alliance Foundation Trials, LLC (AFT) will present data from PRESTO (AFT-19),...
by Children’s Hospital Boston Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111278 Calorie restriction has long been associated with reduced seizures in epilepsy. New research from Boston Children’s Hospital helps explain how fasting affects neurons in the brain and could lead the way to new approaches that would avoid the need for fasting or restrictive diets. The...
New research provides insight into how an important class of molecules are created and moved in human cells. For years, scientists knew that mitochondria – specialized structures inside cells in the body that are essential for respiration and energy production – were involved in the assembly and movement of iron-sulfur cofactors, some of the essential compounds...
UNIVERSITY OF BASEL Overweight increases the risk of an imbalance in sugar metabolism and even of diabetes. A research group at the University of Basel has now shown the opposite is true as well: deficits in the body’s insulin production contribute to overweight. Poor nutrition, too little movement and too many pounds on the scale...
by Aarhus University Credit: Pixabay/CC0 Public Domain Can you eat your way out of a kidney disease? Perhaps you can—according to a new study from Aarhus University. In the study, Associate Professor Markus Rinschen from Aarhus Institute of Advanced Studies and Department of Biomedicine has shown that the intake of the amino acid lysine, an over-the-counter...
by Weill Cornell Medical College Illustration of human liver anatomy. Credit: Shutterstock When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type 2...
by Weill Cornell Medical College Illustration of human liver anatomy. Credit: Shutterstock When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type...
by Van Andel Research Institute Credit: CC0 Public Domain The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function—including some long thought to be cellular waste products. The findings, published today in Cell Metabolism, lay the foundation for future personalized dietary recommendations designed to supercharge...
by Jacqueline Mitchell, Beth Israel Deaconess Medical Center CUL2 controls PRDM16 protein stability and beige fat biogenesis. a, Immunoblotting of Flag-tagged PRDM16 protein in HEK293T cells co-expressing Myc-tagged cullin proteins or an empty vector (Vec). b, Immunoblotting of endogenous PRDM16 protein in inguinal adipocytes overexpressing (OE) Flag-tagged CUL2 or Vec. β-Actin was used as the loading control. c,...
